Evidence map›Paper›PMID 27103427›Full record

Observational studyWorld journal of urology2016

LHRH analog therapy is associated with worse metabolic side effects than bilateral orchiectomy in prostate cancer.

Andreza Vargas, Roberto Dias Machado, Daniel Ianni Filho, Carlos Eduardo Paiva, Rodolfo Borges Dos Reis, Marcos Tobias-Machado, Eliney Ferreira Faria

Open access · greenAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in World journal of urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
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  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andreza VargasDepartment of Urology, Barretos Cancer Hospital, Antenor Duarte Vilela St, 1331, Bairro Dr Paulo Prata, Barretos, CEP: 14.784.400, Brazil.
Roberto Dias MachadoDepartment of Urology, Barretos Cancer Hospital, Antenor Duarte Vilela St, 1331, Bairro Dr Paulo Prata, Barretos, CEP: 14.784.400, Brazil.
Daniel Ianni FilhoDepartment of Urology, Barretos Cancer Hospital, Antenor Duarte Vilela St, 1331, Bairro Dr Paulo Prata, Barretos, CEP: 14.784.400, Brazil.
Carlos Eduardo PaivaDepartment of Urology, Barretos Cancer Hospital, Antenor Duarte Vilela St, 1331, Bairro Dr Paulo Prata, Barretos, CEP: 14.784.400, Brazil.
Rodolfo Borges Dos ReisDepartment of Urology, University of São Paulo, Av. Bandeirantes, 3.900 Monte Alegre, Ribeirão Prêto, SP, CEP: 14040-900, Brazil.
Marcos Tobias-MachadoDepartment of Urology, ABC Medical School, Av. Príncipe de Gales, 821 - Príncipe de Gales, Santo André, SP, CEP: 09060-650, Brazil.
Eliney Ferreira FariaDepartment of Urology, Barretos Cancer Hospital, Antenor Duarte Vilela St, 1331, Bairro Dr Paulo Prata, Barretos, CEP: 14.784.400, Brazil. elineyferreirafaria@yahoo.com.br.
Hospital de Câncer de Barretos · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe morbidity associated with metabolic syndrome induced by androgen deprivation therapy (ADT) in prostate cancer (PCa) has not been widely studied. There are no studies comparing surgical and pharmacological castration with regards to their metabolic side effects. The aim of this study was to compare both modalities.

methodsA prospective observational study was conducted in men with PCa and with indications of any ADT. The participants were divided into two groups: (1) bilateral orchiectomy and (2) LHRH analogs. The metabolic profile was assessed before and during the period of ADT. Bioelectrical impedance analysis (BIA) and bone mineral density were measured before and after 6 months of treatment. The data were analyzed using the Chi-squared test, Student's t test, Bonferroni's test, and ANOVA.

resultsWe enrolled 102 men for analysis, of whom 46 (54.9 %) had been subjected to bilateral orchiectomy and 56 (54.9 %) had been subjected to treatment with LHRH analogs. The basal metabolic profile, body mass index, and BIA were similar between the two groups. The oncologic control (PSA and testosterone) was also similar in both groups. In the intergroup comparison, insulin resistance (p = 0.044) and hemoglobin (p = 0.001) were worse in the group that used LHRH analogs, which was mainly diabetic patients (p = 0.007).

conclusionThis study showed that LHRH analogs had worse effects relative to insulin resistance, mainly in diabetic patients, and induced more anemia and bone demineralization compared to surgical castration. Further prospective, randomized, and comparative studies are needed for metabolic syndrome in ADT modalities.

Indexed as

AgedAged, 80 and overAntineoplastic Agents, HormonalBrazilFollow-Up StudiesGonadotropin-Releasing HormoneHumansIncidenceInsulin ResistanceMaleMetabolic SyndromeMiddle AgedOrchiectomyProspective StudiesProstate-Specific AntigenProstatic NeoplasmsAntineoplastic Agents, HormonalGonadotropin-Releasing HormoneProstate-Specific AntigenTestosteroneAndrogen deprivation therapyMetabolic syndromeProstate cancer

Identifiers

PMID27103427
OpenAlexW2335856072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.