Evidence map›Paper›PMID 27103395›Full record

ArticleJournal of neurovirology2016

Interleukin-12 (-1188) A/C and interferon-γ (+874) A/T gene polymorphisms in subacute sclerosing panencephalitis patients.

Nihal Olgac Dundar, Pinar Gencpinar, Nilgun Sallakci, Ozgur Duman, Senay Haspolat, Banu Anlar, Olcay Yegin

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Article in Journal of neurovirology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Alcohol and multiple sclerosis: an immune system-based review.International journal of physiology, pathophysiology and pharmacology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Nihal Olgac DundarDepartment of Pediatric Neurology, Katip Çelebi University, Izmir, Turkey. nodundar@gmail.com.
Pinar GencpinarDepartment of Pediatric Neurology, Tepecik Training of Research Hospital, Izmir, Turkey.
Nilgun SallakciAkdeniz University Health Sciences Research Centre, Akdeniz University, Antalya, Turkey.
Ozgur DumanDepartment of Pediatric Neurology, Akdeniz University, Antalya, Turkey.
Senay HaspolatDepartment of Pediatric Neurology, Akdeniz University, Antalya, Turkey.
Banu AnlarDepartment of Pediatric Neurology, Hacettepe University, Ankara, Turkey.
Olcay YeginDepartment of Pediatric Immunology, Akdeniz University, Antalya, Turkey.
Akdeniz University · TRHacettepe University · TRIzmir Kâtip Çelebi University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The two polymorphisms [IL-12 (-1188) A/C and the IFN-γ (+874) A/T)] are known to have functional consequences and henceforth were analyzed in subacute sclerosing panencephalitis (SSPE) patients to reveal a possible relation with these polymorphisms and this debilitating disease. For the IL-12 (-1188) A/C polymorphism, 78 patients and 90 healthy individuals were analyzed. An increase in the AA genotype was determined (p = 0.02, OR = 2.06). There was also a statistically significant difference between the control group and the patients with respect to the allele frequencies (p = 0.04, OR = 1.65). For the IFN-γ (+874) A/T polymorphism, 69 SSPE patients and 115 controls were studied and there was not a significant difference between the two groups. Our findings suggested that not the IFN-γ (+874) A/T but the IL-12 (-1188) A/C polymorphism is correlated with SSPE and having an AA genotype or A allele decreases the risk of developing SSPE by 2.06- and 1.65-fold, respectively.

Indexed as

GenotypePolymorphism, Single NucleotideAllelesCase-Control StudiesGene ExpressionGene FrequencyHumansInterferon-gammaInterleukin-12Measles virusPromoter Regions, GeneticProtective FactorsSubacute Sclerosing PanencephalitisIFNG protein, humanInterferon-gammaInterleukin-12Gene polymorphismIFN-γIL-12SSPESubacute sclerosing panencephalitis

Identifiers

PMID27103395
OpenAlexW2342180123

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.