Evidence map›Paper›PMID 27103261›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2016

The short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients.

Sharon K Inouye, Edward R Marcantonio, Cyrus M Kosar, Douglas Tommet, Eva M Schmitt, Thomas G Travison, Jane S Saczynski, Long H Ngo, David C Alsop, Richard N Jones

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 241 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
241citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03342989 naterminatednot on this mapstarted 2018, after this paper: background citation

Speed of Processing Training for Cognitive Deficits After Delirium in Older Adults

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2018 to 2020Enrolled17ConditionsDelirium, DementiaArmsSpeed of Processing Training, Internet-Based Contact Control
NCT04125121 nacompletednot on this mapstarted 2019, after this paper: background citation

Neuroplasticity Induced by General Anaesthesia

TypeinterventionalSponsorSigne Sloth MadsenRan2019 to 2021Enrolled20ConditionsHealthy Volunteers, General Anaesthesia, NeuroplasticityArmsSevoflurane-propofol
3 · Its place in the literature

Who cites it

241 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Cognitive Outcomes After Hip Fracture Surgery: The Association of Postoperative Delirium on Previously Cognitively Normal Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026
    Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

181 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sharon K InouyeDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Aging Brain Center, Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Edward R MarcantonioDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Aging Brain Center, Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Cyrus M KosarAging Brain Center, Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Douglas TommetAging Brain Center, Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA; Departments of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI, USA.
Eva M SchmittAging Brain Center, Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Thomas G TravisonDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Aging Brain Center, Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
Jane S SaczynskiAging Brain Center, Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA; Department of Health Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, MA, USA.
Long H NgoDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
David C AlsopDepartment of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Richard N JonesAging Brain Center, Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA; Departments of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI, USA. Electronic address: Richard_Jones@Brown.edu.

Funding

The Role of Inflammation in the Pathophysiology of Delirium and its Associated Long-Term Cognitive DeclineP01AG031720 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2010 to 2022
$26.7M
READI-SET-GO: Researching Efficient Approaches to Delirium Identification - Sustaining Effective Translation to create Gero-friendly OrganizationsR01AG030618 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI DONNA Marie FICK, EDWARD R MARCANTONIO · 2008 to 2026
$7.9M
Development and Validation of a Delirium Severity ToolkitR01AG044518 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K., JONES, RICHARD N · 2014 to 2024
$7.3M
Mid-Career Mentoring Award for Patient-Oriented Research in AgingK24AG035075 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MARCANTONIO, EDWARD R · 2010 to 2021
$1.9M
K07 Leadership GrantK07AG041835 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2013 to 2017
$656k
NIA NIH HHS K07 AG041835NIA NIH HHS K24 AG035075NIA NIH HHS P01 AG031720NIA NIH HHS R01 AG030618NIA NIH HHS R01 AG044518
6 · The paper itself

Abstract

introductionAs the relationship between delirium and long-term cognitive decline has not been well-explored, we evaluated this association in a prospective study.

methodsSAGES is an ongoing study involving 560 adults age 70 years or more without dementia scheduled for major surgery. Delirium was assessed daily in the postoperative period using the Confusion Assessment Method. General Cognitive Performance (GCP) and the Informant Questionnaire for Cognitive Decline in the Elderly were assessed preoperatively then repeatedly out to 36 months.

resultsOn average, patients with postoperative delirium had significantly lower preoperative cognitive performance, greater immediate (1 month) impairment, equivalent recovery at 2 months, and significantly greater long-term cognitive decline relative to the nondelirium group. Proxy reports corroborated the clinical significance of the long-term cognitive decline in delirious patients. DISCUSSION: Cognitive decline after surgery is biphasic and accelerated among persons with delirium. The pace of long-term decline is similar to that seen with mild cognitive impairment.

Indexed as

Postoperative ComplicationsAgedCognition DisordersDeliriumFemaleHospitalizationHumansLongitudinal StudiesMaleNeuropsychological TestsProspective StudiesPsychiatric Status Rating ScalesRisk FactorsAcute confusional stateCognitive declineDeliriumDementiaGeriatricsMild cognitive impairmentSurgical complicationsSurgical outcomes

Identifiers

PMID27103261
PMCPMC4947419

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.