ArticleEpidemiology and infection2016
Escherichia coli type III secretion system 2 (ETT2) is widely distributed in avian pathogenic Escherichia coli isolates from Eastern China.
Article in Epidemiology and infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- Article
- Drug resistance and pathogenicity characteristics ofFrontiers in veterinary science · 2025Article
- Genetic distribution, characterization, and function ofiScience · 2024Review
- EspE3 plays a role in the pathogenicity of avian pathogenic Escherichia coli.Veterinary research · 2023Article
- Global Genomic Epidemiology ofMicroorganisms · 2022Article
- Characteristics, pathogenic mechanism, zoonotic potential, drug resistance, and prevention of avian pathogenicFrontiers in microbiology · 2022Review
- Transcription Regulator YgeK Affects the Virulence of Avian PathogenicAnimals : an open access journal from MDPI · 2021Article
- DctR contributes to the virulence of avian pathogenic Escherichia coli through regulation of type III secretion system 2 expression.Veterinary research · 2021Article
- Characterization of a Broad-Host-Range Lytic Phage SHWT1 Against Multidrug-ResistantFrontiers in veterinary science · 2021Article
- Transcriptional Regulator YqeI, Locating at ETT2 Locus, Affects the Pathogenicity of Avian PathogenicAnimals : an open access journal from MDPI · 2020Article
- Article
- Escherichia coli Type III Secretion System 2 ATPase EivC Is Involved in the Motility and Virulence of Avian Pathogenic Escherichia coli.Frontiers in microbiology · 2016Article
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10 authors.
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Abstract
Pathogens utilize type III secretion systems to deliver effector proteins, which facilitate bacterial infections. The Escherichia coli type III secretion system 2 (ETT2) which plays a crucial role in bacterial virulence, is present in the majority of E. coli strains, although ETT2 has undergone widespread mutational attrition. We investigated the distribution and characteristics of ETT2 in avian pathogenic E. coli (APEC) isolates and identified five different ETT2 isoforms, including intact ETT2, in 57·6% (141/245) of the isolates. The ETT2 locus was present in the predominant APEC serotypes O78, O2 and O1. All of the ETT2 loci in the serotype O78 isolates were degenerate, whereas an intact ETT2 locus was mostly present in O1 and O2 serotype strains, which belong to phylogenetic groups B2 and D, respectively. Interestingly, a putative second type III secretion-associated locus (eip locus) was present only in the isolates with an intact ETT2. Moreover, ETT2 was more widely distributed in APEC isolates and exhibited more isoforms compared to ETT2 in human extraintestinal pathogenic E. coli, suggesting that APEC might be a potential risk to human health. However, there was no distinct correlation between ETT2 and other virulence factors in APEC.
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