Evidence map›Paper›PMID 27102989›Full record

ArticleBMC infectious diseases2016

Sero-epidemiological assessment of Chlamydia trachomatis infection and sub-fertility in Samoan women.

S Menon, S H Stansfield, M Walsh, E Hope, L Isaia, A A Righarts, T Niupulusu, S V A Temese, L Iosefa-Siitia, L Auvaa and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Infertility and Auto-Antibodies: A Review.Antibodies (Basel, Switzerland) · 2025
    Review
  2. Article
  3. Review
  4. Exposure toVaccines · 2022
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

S MenonInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
S H StansfieldInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
M WalshCentre for International Health, University of Otago, Dunedin, New Zealand.
E HopeNational University of Samoa, Apia, Samoa.
L IsaiaNational Health Service Laboratory Division, Apia, Samoa.
A A RighartsCentre for International Health, University of Otago, Dunedin, New Zealand.
T NiupulusuSamoa Family Health Association, Apia, Samoa.
S V A TemeseCentre for Samoan Studies, National University of Samoa, Apia, Samoa.
L Iosefa-SiitiaSamoa National Council of Churches, Apia, Samoa.
L AuvaaNational University of Samoa, Apia, Samoa.
S A TapeluSamoa AIDS Foundation, Apia, Samoa.
M F MotuSamoa National Council of Churches, Apia, Samoa.
T Suaalii-SauniVictoria University of Wellington, Wellington, New Zealand.
P TimmsFaculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore, Australia.
P C HillCentre for International Health, University of Otago, Dunedin, New Zealand.
W M HustonInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia. Wilhelmina.Huston@uts.edu.au.
National University of Samoa · WSUniversity of Otago · NZQueensland University of Technology · AUUniversity of Technology Sydney · AUUniversity of the Sunshine Coast · AUVictoria University of Wellington · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn our recent village-based cross-sectional study, the prevalence of nucleic acid amplification technique (NAAT) diagnosed Chlamydia trachomatis (CT) in sexually active Samoan women was very high (36 %), and test positivity was associated with sub-fertility. We conducted a serological and epidemiological analysis in these participants to identify if serological data can provide further insight into the potential contribution of CT to sub-fertility in this population.

methodsSerological prediction of CT associated sub-fertility was conducted using a series of commercial tests. The correlation between fertility or sub-fertility, behavioral factors, and serologically predicted CT associated sub-fertility was determined.

resultsA positive antibody reaction against the Chlamydia Major Outer Membrane Protein (MOMP) was significantly associated with sub-fertility, with 50 % of infertile women being positive. Serum IgG and IgA antibodies against MOMP correlated with current infection measured by urine NAAT, suggesting longer term infections are common in this population. Chlamydia pneumoniae antibodies were frequently detected in this population (84 %), and unexpectedly, were significantly associated with sub-fertility.

conclusionsThe high prevalence of chlamydial infection and of positive chlamydial sub-fertility results suggests that CT is an important and frequent contributory factor to sub-fertility in this population.

Indexed as

AdolescentAdultAntibodies, BacterialBacterial Outer Membrane ProteinsChlamydia InfectionsChlamydia trachomatisCross-Sectional StudiesDNA, BacterialEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin AImmunoglobulin GInfertility, FemalePolymerase Chain ReactionSamoaAntibodies, BacterialBacterial Outer Membrane ProteinsDNA, BacterialImmunoglobulin AImmunoglobulin GChlamydiadiagnosisfemale sub-fertilityPacific islandssamoaserology

Identifiers

PMID27102989
PMCPMC4839085
OpenAlexW2342003420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.