ArticleProceedings of the National Academy of Sciences of the United States of America2016
Receptor arrays optimized for natural odor statistics.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed.
- Undoing of firing rate adaptation enables invariant population codes.Science advances · 2026Article
- Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Simultaneous detection and estimation in olfactory sensing.bioRxiv : the preprint server for biology · 2025Article
- When noncanonical olfaction is optimal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding.bioRxiv : the preprint server for biology · 2025Article
- Limits on the computational expressivity of non-equilibrium biophysical processes.Nature communications · 2025Article
- The primacy model and the structure of olfactory space.PLoS computational biology · 2024Article
- Neural Circuits for Fast Poisson Compressed Sensing in the Olfactory Bulb.bioRxiv : the preprint server for biology · 2023Article
- Nonequilibrium sensing of volatile compounds using active and passive analyte delivery.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Functional imaging and quantification of multineuronal olfactory responses inScience advances · 2023Article
- Neural Circuits for Fast Poisson Compressed Sensing in the Olfactory Bulb.Advances in neural information processing systems · 2023Article
- Mosquito Olfactory Response Ensemble enables pattern discovery by curating a behavioral and electrophysiological response database.iScience · 2022Article
- Disorder and the Neural Representation of Complex Odors.Frontiers in computational neuroscience · 2022Article
- Article
- What the odor is not: Estimation by elimination.Physical review. E · 2021Article
- Nonlinear convergence boosts information coding in circuits with parallel outputs.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Nonlinear mixed selectivity supports reliable neural computation.PLoS computational biology · 2020Article
- Optimal compressed sensing strategies for an array of nonlinear olfactory receptor neurons with and without spontaneous activity.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Primacy coding facilitates effective odor discrimination when receptor sensitivities are tuned.PLoS computational biology · 2019Article
- Article
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3 authors.
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Abstract
Natural odors typically consist of many molecules at different concentrations. It is unclear how the numerous odorant molecules and their possible mixtures are discriminated by relatively few olfactory receptors. Using an information theoretic model, we show that a receptor array is optimal for this task if it achieves two possibly conflicting goals: (i) Each receptor should respond to half of all odors and (ii) the response of different receptors should be uncorrelated when averaged over odors presented with natural statistics. We use these design principles to predict statistics of the affinities between receptors and odorant molecules for a broad class of odor statistics. We also show that optimal receptor arrays can be tuned to either resolve concentrations well or distinguish mixtures reliably. Finally, we use our results to predict properties of experimentally measured receptor arrays. Our work can thus be used to better understand natural olfaction, and it also suggests ways to improve artificial sensor arrays.
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