ArticleScientific reports2016
Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Nordic diet and chronic disease: a GRADE-assessed systematic review and meta-analysis of prospective cohorts and randomized controlled trials.European journal of nutrition · 2025Pooled it
- Trial
- High-Intensity Training Reduces CVD Risk Factors among Rotating Shift Workers: An Eight-Week Intervention in Industry.International journal of environmental research and public health · 2020Trial
- Four nights of sleep restriction suppress the postprandial lipemic response and decrease satiety.Journal of lipid research · 2019Trial
- Article
- Association Between Sleep Patterns and the Risk of Cardiometabolic Diseases or Cardiometabolic Multimorbidity and the Mediating Role of Metabolic Biomarkers: A Prospective Study of the UK Biobank Cohort.Healthcare (Basel, Switzerland) · 2026Article
- A novel biological interpretation of neuropsychiatric symptoms in patients with allergic rhinitis: insights from brain functional connectivity gradient and serum multi-omics analysis.BMC medical imaging · 2026Article
- Exploratory NMR-based metabolomics reveals transient lipoprotein changes during prolonged computer gaming.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Leveraging the Metabolic Fingerprint of Sleep Deprivation and Sleep Restriction for Forensic Applications: A Machine Learning Study in Oral Fluid Metabolomics.Journal of proteome research · 2026Article
- Causal relationships between insomnia and blood metabolome: a Mendelian randomization study with mouse experimental validation.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Sleep regulates hepatic neutrophil trafficking by modulating uric acid metabolism via sympathetic nervous system activity.bioRxiv : the preprint server for biology · 2026Article
- Association between high-density lipoprotein-related inflammation index and prevalence of sleep disorders with depression as a mediator.European archives of psychiatry and clinical neuroscience · 2026Article
- Cell-specific effects of acute sleep deprivation on transcriptomic signatures of non-neuronal cells in the mouse hippocampus and prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- Effect of Constant Illumination and Melatonin Administration on the Lifespan in Rats.Bulletin of experimental biology and medicine · 2026Article
- Daytime nap and nighttime sleep duration in relation to dyslipidemia among type 2 diabetes patients in eastern China: a cross-sectional study.Frontiers in nutrition · 2026Article
- Association of Sleep Duration, Metabolic Markers, and Risk of All-Cause and Cause-Specific Mortality in China and the UK.Global heart · 2026Article
- From probiotic depletion to inflammatory cascade: multi-omics reveals the temporal progression of sleep deprivation-induced gut-liver axis disruption in mice.Frontiers in microbiology · 2026Article
- A [Journal of neuroinflammation · 2025Article
- Assessing the association between multiple indicators of inflammation and sleep disorders in young and middle-aged women: insights from traditional and machine learning approaches.European journal of medical research · 2025Article
- Rotating shift work, with night shift work, affects cardiovascular risk factors: a 6-year follow-up study in the insulation industry.Occupational and environmental medicine · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
26 authors at 16 institutions in 3 countries.
Funding
Abstract
Sleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on how insufficient sleep contributes to these diseases are scarce. These questions were addressed using two approaches: an experimental, partial sleep restriction study (14 cases and 7 control subjects) with objective verification of sleep amount, and two independent epidemiological cohorts (altogether 2739 individuals) with questions of sleep insufficiency. In both approaches, blood transcriptome and serum metabolome were analysed. Sleep loss decreased the expression of genes encoding cholesterol transporters and increased expression in pathways involved in inflammatory responses in both paradigms. Metabolomic analyses revealed lower circulating large HDL in the population cohorts among subjects reporting insufficient sleep, while circulating LDL decreased in the experimental sleep restriction study. These findings suggest that prolonged sleep deprivation modifies inflammatory and cholesterol pathways at the level of gene expression and serum lipoproteins, inducing changes toward potentially higher risk for cardiometabolic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.