ReviewEnvironmental science and pollution research international2016
Exposure, epidemiology, and mechanism of the environmental toxicant manganese.
Review in Environmental science and pollution research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed.
- Neuron-specific modulation of SLC30A10 identifies dopaminergic and glutamatergic neurons as targets of manganese-induced motor disease.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A versatile Lepidium sativum bioassay for use in ecotoxicological studies.Scientific reports · 2025Article
- The Role of Epigenetics in Manganese Neurotoxicity: An Update with a Focus on Non-Coding RNAs and Histone Modifications.Neurochemical research · 2025Review
- Consensus of Expert Opinion for the Diagnosis and Management of Hypermanganesaemia With Dystonia 1 and 2.Journal of inherited metabolic disease · 2025Article
- Elevated brain manganese induces motor disease by upregulating the kynurenine pathway of tryptophan metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Manganese and Vanadium Co-Exposure Induces Severe Neurotoxicity in the Olfactory System: Relevance to Metal-Induced Parkinsonism.International journal of molecular sciences · 2024Article
- The association of manganese levels with red cell distribution width: A population-based study.PloS one · 2024Article
- Review
- The association between blood manganese and liver stiffness in participants with chronic obstructive pulmonary disease: a cross-sectional study from NHANES 2017-2018.European journal of medical research · 2023Article
- An adjusted partial least squares regression framework to utilize additional exposure information in environmental mixture data analysis.Journal of applied statistics · 2023Article
- Association between gestational levels of toxic metals and essential elements and cerebral palsy in children.Frontiers in neurology · 2023Article
- Association between Blood Manganese Levels and Visceral Adipose Tissue in the United States: A Population-Based Study.Nutrients · 2022Article
- Article
- Clinical relevance of environmental manganese exposure with liver stiffness and steatosis detected by transient elastography in adults.Environmental science and pollution research international · 2022Article
- The association of bone and blood manganese with motor function in Chinese workers.Neurotoxicology · 2022Article
- Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies.Frontiers in pharmacology · 2022Review
- Review on the Use of Heavy Metal Deposits from Water Treatment Waste towards Catalytic Chemical Syntheses.International journal of molecular sciences · 2021Review
- Determination and health risk assessment of trace elements in the tap water of two Sub-Cities of Addis Ababa, Ethiopia.Heliyon · 2021Article
- Critical Involvement of Glial Cells in Manganese Neurotoxicity.BioMed research international · 2021Review
- New directions in understanding the role of environmental contaminants in child development: Four themes.New directions for child and adolescent development · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has become increasingly apparent that global manganese (Mn) pollution to air and water is a significant threat to human health. Despite this recognition, research is only beginning to comprehend the detrimental effects of exposure. Mn, while essential, is particularly harmful to the central nervous system, and overexposure is symptomatic of several neurological disorders. At-risk populations have been identified, but it is still unclear whether typical exposure levels have any long-term consequences. Those at an elevated risk have diminished intellectual function, learning and memory, and mental development. While the overall mechanism of toxicity is undetermined, Mn has been found to induce oxidative stress, exacerbate mitochondrial dysfunction, dysregulate autophagy, and promote apoptosis, ultimately enhancing neurodegeneration. Extrapolation of this in vitro and in vivo data to humans is difficult. There is a definite need to correlate epidemiological studies with causative effects. It is imperative that research efforts endure, so threats are appropriately identified and exposure properly regulated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.