Evidence map›Paper›PMID 27102537›Full record

ReviewGenome medicine2016

Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions.

Linda S Zhang, Sean S Davies

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genome medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 284 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
284citing papers in PubMed, 5 pooled it
23.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

284 citing papers in PubMed, 5 syntheses or guidelines pooled it, 490 citations in OpenAlex.

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224 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Linda S ZhangDivision of Clinical Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA.
Sean S DaviesDivision of Clinical Pharmacology, Vanderbilt University, Nashville, TN, 37232, USA. sean.davies@vanderbilt.edu.
Vanderbilt University · US

Funding

Therapeutically Modified Gut Bacteria for Treatment of ObesityR01AT007830 · NCCIH · VANDERBILT UNIVERSITY · PI DAVIES, SEAN STEPHEN · 2013 to 2017
$1.8M
NCCIH NIH HHS AT007830NCCIH NIH HHS R01 AT007830
6 · The paper itself

Abstract

Mass spectrometry- and nuclear magnetic resonance-based metabolomic studies comparing diseased versus healthy individuals have shown that microbial metabolites are often the compounds most markedly altered in the disease state. Recent studies suggest that several of these metabolites that derive from microbial transformation of dietary components have significant effects on physiological processes such as gut and immune homeostasis, energy metabolism, vascular function, and neurological behavior. Here, we review several of the most intriguing diet-dependent metabolites that may impact host physiology and may therefore be appropriate targets for therapeutic interventions, such as short-chain fatty acids, trimethylamine N-oxide, tryptophan and tyrosine derivatives, and oxidized fatty acids. Such interventions will require modulating either bacterial species or the bacterial biosynthetic enzymes required to produce these metabolites, so we briefly describe the current understanding of the bacterial and enzymatic pathways involved in their biosynthesis and summarize their molecular mechanisms of action. We then discuss in more detail the impact of these metabolites on health and disease, and review current strategies to modulate levels of these metabolites to promote human health. We also suggest future studies that are needed to realize the full therapeutic potential of targeting the gut microbiota.

Indexed as

DietEnergy MetabolismMetabolomeMicrobiotaAnimalsDisease SusceptibilityFatty Acids, VolatileGastrointestinal MicrobiomeGastrointestinal TractHomeostasisHumansIndolesMetabolomicsMethylaminesTranslational Research, BiomedicalTryptophanFatty Acids, VolatileindoleIndolesMethylaminestrimethyloxamineTryptophanTyrosine

Identifiers

PMID27102537
PMCPMC4840492
OpenAlexW2339856074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.