ArticleJournal of cancer research and clinical oncology2016
The relationship of cognitive performance to concurrent symptoms, cancer- and cancer-treatment-related variables in women with early-stage breast cancer: a 2-year longitudinal study.
Article in Journal of cancer research and clinical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cognitive Effects and Depression Associated With Taxane-Based Chemotherapy in Breast Cancer Survivors: A Meta-Analysis.Frontiers in oncology · 2021Pooled it
- Systematic review of cognitive sequelae of non-central nervous system cancer and cancer therapy.Journal of cancer survivorship : research and practice · 2020Pooled it
- Adding high-intensity interval training to conventional training modalities: optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial.Breast cancer research and treatment · 2018Trial
- Racial Disparities in Psychoneurological Symptoms and Health-Promoting Behaviors Among Breast Cancer Survivors: A Two-Year Longitudinal Study.Oncology nursing forum · 2026Article
- Trajectories and related factors of subjective cognitive function in patients living with breast cancer receiving postoperative chemotherapy: a latent class growth model study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Profiling of psychoneurological symptoms in newly diagnosed head and neck cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- "It Was a Downward Spiral": A Qualitative Study of Young Adult Cancer Survivors' Experiences with Cognitive and Mental Health.Cancers · 2024Article
- Altered gyrification in chemotherapy-treated older long-term breast cancer survivors.Brain and behavior · 2024Article
- Remote, Computerised Cognitive Assessment for Breast Cancer- and Treatment-Related Cognitive Dysfunction: Psychometric Characteristics of the Cogsuite Neurocognitive Battery.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2023Article
- A scoping review of psychological distress instruments in women with early-stage breast cancer during chemotherapy.Cancer reports (Hoboken, N.J.) · 2023Article
- Article
- Changes in Attentional Function in Patients From Before Through 12 Months After Breast Cancer Surgery.Journal of pain and symptom management · 2020Article
- Cortical Brain Age from Pre-treatment to Post-chemotherapy in Patients with Breast Cancer.Neurotoxicity research · 2020Article
- Effects of chemotherapy on aging white matter microstructure: A longitudinal diffusion tensor imaging study.Journal of geriatric oncology · 2020Article
- Cytokine-associated fatigue prior to, during, and post-chemotherapy for breast cancer.Journal of neuroimmunology · 2019Article
- Relationship of fatigue with cognitive performance in women with early-stage breast cancer over 2 years.Psycho-oncology · 2019Article
- Pretreatment Psychoneurological Symptoms and Their Association With Longitudinal Cognitive Function and Quality of Life in Older Breast Cancer Survivors.Journal of pain and symptom management · 2019Article
- Neurocognitive dysfunction in hematopoietic cell transplant recipients: expert review from the late effects and Quality of Life Working Committee of the CIBMTR and complications and Quality of Life Working Party of the EBMT.Bone marrow transplantation · 2018Review
- Neurocognitive Dysfunction in Hematopoietic Cell Transplant Recipients: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Complications and Quality of Life Working Party of the European Society for Blood and Marrow Transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2018Review
- Relationships among psychoneurological symptoms and levels of C-reactive protein over 2 years in women with early-stage breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
purposeCognitive dysfunction in women with breast cancer continues to be an area of intense research interest. The prevalence, severity, timing, and cognitive domains that are most affected, as well as the contribution of cancer and its treatments to cognition, remain unresolved. Thus, longitudinal studies are needed that examine cognitive function during different stages of breast cancer treatment and survivorship. This longitudinal trial followed women with early-stage breast cancer, prior to chemotherapy through 2 years survivorship.
methodsIn women with early-stage breast cancer (N = -75), performance-based assessment of nine cognitive domains was performed at five time points beginning prior to chemotherapy and finishing 24 months after initial chemotherapy. Linear mixed effects models were used to examine the temporal changes in cognitive performance domains, while adjusting for cofactors, including those related to individuals, tumor attributes, chemotherapy (adjuvant or neoadjuvant), radiation, endocrine therapy, and concurrent symptoms.
resultsAt baseline, scores on reaction time, complex attention, cognitive flexibility, executive function, and visual memory were lower than 90. At 2 years, all domains improved except for the memory domains (verbal, visual, and composite). Scores on six domains (psychomotor speed, reaction time, complex attention, cognitive flexibility, and visual memory) remained lower than 100 at 2 years. Neoadjuvant chemotherapy and fatigue had strong inverse relationship with cognitive functioning at multiple time points.
conclusionThe low performance-based cognitive scores at baseline and over time warrant further study. Although most scores improved over time, memory did not improve. In all, the level of cognitive function is lower than expected for a majority college-educated sample. Thus, future studies are warranted to replicate these findings and to develop methods for identifying women with cognitive dysfunction pretreatment and into survivorship.
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