Evidence map›Paper›PMID 27102402›Full record

ArticleJournal of the National Cancer Institute2016

Chronic Conditions and Utility-Based Health-Related Quality of Life in Adult Childhood Cancer Survivors.

Jennifer M Yeh, Janel Hanmer, Zachary J Ward, Wendy M Leisenring, Gregory T Armstrong, Melissa M Hudson, Marilyn Stovall, Leslie L Robison, Kevin C Oeffinger, Lisa Diller

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the National Cancer Institute, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 70 citations in OpenAlex.

  1. Benefits, Harms, and Burden of Colorectal Cancer Screening Among Childhood Cancer Survivors Previously Treated With Abdominopelvic Radiation.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026
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  17. Functional Outcomes and Social Attainment in Asian/Pacific Islander Childhood Cancer Survivors in the United States: A Report from the Childhood Cancer Survivor Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Article
  18. Awareness of diagnosis, treatment and risk of late effects in Chinese survivors of childhood cancer in Hong Kong.Health expectations : an international journal of public participation in health care and health policy · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Jennifer M YehCenter for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA (JMY, ZJW); University of Pittsburgh Medical Center, Pittsburgh, PA (JH); Fred Hutchinson Cancer Research Center, Seattle, WA (WML); St. Jude Children's Research Hospital, Memphis, TN (GTA, MMH, LLR); University of Texas MD Anderson Cancer Center, Houston, TX (MS); Memorial Sloan Kettering Cancer Center, New York, NY (KCO); Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA (LD) jyeh@hsph.harvard.edu.
Janel HanmerCenter for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA (JMY, ZJW); University of Pittsburgh Medical Center, Pittsburgh, PA (JH); Fred Hutchinson Cancer Research Center, Seattle, WA (WML); St. Jude Children's Research Hospital, Memphis, TN (GTA, MMH, LLR); University of Texas MD Anderson Cancer Center, Houston, TX (MS); Memorial Sloan Kettering Cancer Center, New York, NY (KCO); Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA (LD).
Zachary J WardCenter for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA (JMY, ZJW); University of Pittsburgh Medical Center, Pittsburgh, PA (JH); Fred Hutchinson Cancer Research Center, Seattle, WA (WML); St. Jude Children's Research Hospital, Memphis, TN (GTA, MMH, LLR); University of Texas MD Anderson Cancer Center, Houston, TX (MS); Memorial Sloan Kettering Cancer Center, New York, NY (KCO); Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA (LD).
Wendy M LeisenringCenter for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA (JMY, ZJW); University of Pittsburgh Medical Center, Pittsburgh, PA (JH); Fred Hutchinson Cancer Research Center, Seattle, WA (WML); St. Jude Children's Research Hospital, Memphis, TN (GTA, MMH, LLR); University of Texas MD Anderson Cancer Center, Houston, TX (MS); Memorial Sloan Kettering Cancer Center, New York, NY (KCO); Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA (LD).
Gregory T ArmstrongCenter for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA (JMY, ZJW); University of Pittsburgh Medical Center, Pittsburgh, PA (JH); Fred Hutchinson Cancer Research Center, Seattle, WA (WML); St. Jude Children's Research Hospital, Memphis, TN (GTA, MMH, LLR); University of Texas MD Anderson Cancer Center, Houston, TX (MS); Memorial Sloan Kettering Cancer Center, New York, NY (KCO); Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA (LD).
Melissa M HudsonCenter for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA (JMY, ZJW); University of Pittsburgh Medical Center, Pittsburgh, PA (JH); Fred Hutchinson Cancer Research Center, Seattle, WA (WML); St. Jude Children's Research Hospital, Memphis, TN (GTA, MMH, LLR); University of Texas MD Anderson Cancer Center, Houston, TX (MS); Memorial Sloan Kettering Cancer Center, New York, NY (KCO); Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA (LD).
Marilyn StovallCenter for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA (JMY, ZJW); University of Pittsburgh Medical Center, Pittsburgh, PA (JH); Fred Hutchinson Cancer Research Center, Seattle, WA (WML); St. Jude Children's Research Hospital, Memphis, TN (GTA, MMH, LLR); University of Texas MD Anderson Cancer Center, Houston, TX (MS); Memorial Sloan Kettering Cancer Center, New York, NY (KCO); Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA (LD).
Leslie L RobisonCenter for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA (JMY, ZJW); University of Pittsburgh Medical Center, Pittsburgh, PA (JH); Fred Hutchinson Cancer Research Center, Seattle, WA (WML); St. Jude Children's Research Hospital, Memphis, TN (GTA, MMH, LLR); University of Texas MD Anderson Cancer Center, Houston, TX (MS); Memorial Sloan Kettering Cancer Center, New York, NY (KCO); Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA (LD).
Kevin C OeffingerCenter for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA (JMY, ZJW); University of Pittsburgh Medical Center, Pittsburgh, PA (JH); Fred Hutchinson Cancer Research Center, Seattle, WA (WML); St. Jude Children's Research Hospital, Memphis, TN (GTA, MMH, LLR); University of Texas MD Anderson Cancer Center, Houston, TX (MS); Memorial Sloan Kettering Cancer Center, New York, NY (KCO); Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA (LD).
Lisa DillerCenter for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA (JMY, ZJW); University of Pittsburgh Medical Center, Pittsburgh, PA (JH); Fred Hutchinson Cancer Research Center, Seattle, WA (WML); St. Jude Children's Research Hospital, Memphis, TN (GTA, MMH, LLR); University of Texas MD Anderson Cancer Center, Houston, TX (MS); Memorial Sloan Kettering Cancer Center, New York, NY (KCO); Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA (LD).
St. Jude Children's Research Hospital · USUniversity of Pittsburgh Medical Center · USFred Hutch Cancer Center · USThe University of Texas MD Anderson Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SUZANNE J. BAKER · 1985 to 2026
$166.9M
Mach-LETSGO: Machine-LEarning of Treatment, Survey, and Genetics towards Obtaining Correct Classification of Chronic Conditions in Adult Survivors in the Childhood Cancer Survivor Study - CCSS SupplU24CA055727 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Gregory Armstrong · 1999 to 2026
$96.7M
Gastric Cancer Prevention: Evaluating U.S. Risk Factor Trends and New TechnologyK07CA143044 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI YEH, JENNIFER M. · 2010 to 2014
$751k
NCI NIH HHS K07 CA143044NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA021765NCI NIH HHS U24 CA055727
6 · The paper itself

Abstract

Health utility, a summary measure of quality of life, has not been previously used to compare outcomes among childhood cancer survivors and individuals without a cancer history. We estimated health utility (0, death; 1, perfect health) using the Short Form-6D (SF-6D) in survivors (n = 7105) and siblings of survivors (n = 372) (using the Childhood Cancer Survivor Study cohort) and the general population (n = 12 803) (using the Medical Expenditures Panel Survey). Survivors had statistically significantly lower SF-6D scores than the general population (mean = 0.769, 95% confidence interval [CI] = 0.766 to 0.771, vs mean = 0.809, 95% CI = 0.806 to 0.813, respectively, ITALIC! P< .001, two-sided). Young adult survivors (age 18-29 years) reported scores comparable with general population estimates for people age 40 to 49 years. Among survivors, SF-6D scores were largely determined by number and severity of chronic conditions. No clinically meaningful differences were identified between siblings and the general population (mean = 0.793, 95% CI = 0.782 to 0.805, vs mean = 0.809, 95% CI = 0.806 to 0.813, respectively). This analysis illustrates the importance of chronic conditions on long-term survivor quality of life and provides encouraging results on sibling well-being. Preference-based utilities are informative tools for outcomes research in cancer survivors.

Indexed as

Chronic DiseaseNeoplasmsQuality of LifeSiblingsSurvivorsAdolescentAdultCase-Control StudiesConfidence IntervalsFemaleHumansMaleMiddle AgedSurveys and QuestionnairesYoung Adult

Identifiers

PMID27102402
PMCPMC5939850
OpenAlexW2336136106

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.