Evidence map›Paper›PMID 27102333›Full record

ArticleGenome medicine2016

The influence of a short-term gluten-free diet on the human gut microbiome.

Marc Jan Bonder, Ettje F Tigchelaar, Xianghang Cai, Gosia Trynka, Maria C Cenit, Barbara Hrdlickova, Huanzi Zhong, Tommi Vatanen, Dirk Gevers, Cisca Wijmenga and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06249074 (The Impact of Gluten-free Diet on the Thyroid Function, Quality of Life and Gut Microbiome Composition in Women With Autoimmune Thyroiditis), which is not on this map. Cited by 143 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 8 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06249074 nacompletednot on this mapstarted 2020, after this paper: background citation

The Impact of Gluten-free Diet on the Thyroid Function, Quality of Life and Gut Microbiome Composition in Women With Autoimmune Thyroiditis

TypeinterventionalSponsorMedical University of GdanskRan2020 to 2021Enrolled31ConditionsAutoimmune ThyroiditisArmsGluten-free diet, Gluten capsules supplementation, Placebo capsules supplementation
3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 8 syntheses or guidelines pooled it, 282 citations in OpenAlex.

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  6. Diet, adiposity, and the gut microbiota from infancy to adolescence: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
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  20. New Personalized Medicine Model for Medication Management.Journal of personalized medicine · 2026
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83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 5 countries.

Marc Jan BonderDepartment of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Ettje F TigchelaarDepartment of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Xianghang CaiBGI, Shenzhen, 518083, China.
Gosia TrynkaWellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
Maria C CenitDepartment of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Barbara HrdlickovaDepartment of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Huanzi ZhongBGI, Shenzhen, 518083, China.
Tommi VatanenBroad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Dirk GeversBroad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Cisca WijmengaDepartment of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Yang WangBGI, Shenzhen, 518083, China.
Alexandra ZhernakovaDepartment of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands. sashazhernakova@gmail.com.
BGI Group (China) · CNTiFN · NLUniversity Medical Center Groningen · NLAalto University · FIBroad Institute · USWellcome Sanger Institute · GB

Funding

European Research Council 322698Wellcome TrustWellcome Trust WT098051
6 · The paper itself

Abstract

backgroundA gluten-free diet (GFD) is the most commonly adopted special diet worldwide. It is an effective treatment for coeliac disease and is also often followed by individuals to alleviate gastrointestinal complaints. It is known there is an important link between diet and the gut microbiome, but it is largely unknown how a switch to a GFD affects the human gut microbiome.

methodsWe studied changes in the gut microbiomes of 21 healthy volunteers who followed a GFD for four weeks. We collected nine stool samples from each participant: one at baseline, four during the GFD period, and four when they returned to their habitual diet (HD), making a total of 189 samples. We determined microbiome profiles using 16S rRNA sequencing and then processed the samples for taxonomic and imputed functional composition. Additionally, in all 189 samples, six gut health-related biomarkers were measured.

resultsInter-individual variation in the gut microbiota remained stable during this short-term GFD intervention. A number of taxon-specific differences were seen during the GFD: the most striking shift was seen for the family Veillonellaceae (class Clostridia), which was significantly reduced during the intervention (p = 2.81 × 10(-05)). Seven other taxa also showed significant changes; the majority of them are known to play a role in starch metabolism. We saw stronger differences in pathway activities: 21 predicted pathway activity scores showed significant association to the change in diet. We observed strong relations between the predicted activity of pathways and biomarker measurements.

conclusionsA GFD changes the gut microbiome composition and alters the activity of microbial pathways.

Indexed as

Diet, Gluten-FreeGastrointestinal MicrobiomeAdolescentAdultBiodiversityBiomarkersEatingFemaleGlutensHealthy VolunteersHumansMaleMiddle AgedTime FactorsYoung AdultBiomarkersGlutensBiomarkerGluten-free dietMicrobiomeObservation study

Identifiers

PMID27102333
PMCPMC4841035
OpenAlexW2341437691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.