ArticleAJNR. American journal of neuroradiology2016
Prediction of Carotid Intraplaque Hemorrhage Using Adventitial Calcification and Plaque Thickness on CTA.
Article in AJNR. American journal of neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Carotid Artery Wall Imaging: Perspective and Guidelines from the ASNR Vessel Wall Imaging Study Group and Expert Consensus Recommendations of the American Society of Neuroradiology.AJNR. American journal of neuroradiology · 2018Guideline
- Automated sternocleidomastoid ROI placement on carotid black-blood T1-weighted MRI: toward standardized plaque-to-muscle ratio assessment.Radiological physics and technology · 2026Article
- Plaque-level comparison of carotid CTA and high-resolution magnetic resonance vessel wall imaging for assessing MRI-defined plaque vulnerability.European radiology · 2026Article
- Role of T1-weighted MRI in Identifying Coronary Intraplaque Hemorrhage: CATCH the Truly High-Risk Plaque.Journal of atherosclerosis and thrombosis · 2026Review
- Computed Tomography Angiography "Rim Sign" for Detecting Carotid Intraplaque Hemorrhage: A Computed Tomography Angiography-Magnetic Resonance Imaging-Histology Correlation Study.Journal of the American Heart Association · 2026Article
- A fusion model of deep learning and conventional features based on computed tomography angiography of carotid plaque for predicting the risk of acute ischemic stroke.Quantitative imaging in medicine and surgery · 2026Article
- Study on the correlation between carotid plaque calcification types and the recurrence of ischemic stroke.BMC medical imaging · 2026Article
- Article
- Research on ischemic stroke risk assessment based on CTA radiomics and machine learning.BMC medical imaging · 2025Article
- Many strokes from a single non-stenosing plaque: from the last event a light to the first one?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Association between carotid plaque calcification and clinical outcomes of symptomatic cerebral small vessel disease.Frontiers in neurology · 2025Article
- Study on the correlation between carotid plaque calcification types and acute ischemic stroke.Frontiers in neurology · 2025Article
- Usefulness of cone-beam computed tomography to predict residual stenosis after carotid artery stenting.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024Article
- The role of non-stenosing carotid artery plaques in embolic stroke of undetermined source, is it a silent offender? A review of literature.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024Review
- Prevalence and clinical implications of calcification in internal carotid artery stenosis: a retrospective study.BMC neurology · 2024Article
- Machine learning detects symptomatic patients with carotid plaques based on 6-type calcium configuration classification on CT angiography.European radiology · 2024Article
- Embolic strokes of undetermined source: a clinical consensus statement of the ESC Council on Stroke, the European Association of Cardiovascular Imaging and the European Heart Rhythm Association of the ESC.European heart journal · 2024Article
- Evaluating the association between vascular remodeling and plaque calcification patterns of the carotid artery and its effects on ischemic symptoms using CT angiography.Cardiovascular diagnosis and therapy · 2024Article
- Evaluation of the Correlation Between Distribution Location and Vulnerability of Carotid Plaque in Patients with Transient Ischemic Attack.Vascular health and risk management · 2024Article
- Radiomics Signatures of Carotid Plaque on Computed Tomography Angiography : An Approach to Identify Symptomatic Plaques.Clinical neuroradiology · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
background and purposeCarotid intraplaque hemorrhage is associated with stroke, plaque thickness, stenosis, ulceration, and adventitial inflammation. Conflicting data exist on whether calcification is a marker of plaque instability, and no data exist on adventitial calcification. Our goal was to determine whether adventitial calcification and soft plaque (a rim sign) help predict carotid intraplaque hemorrhage. MATERIALS AND
methodsThis was a retrospective cohort study of 96 patients who underwent carotid MRA and CTA within 1 month, from 2009 to 2016. We excluded occlusions (n = 4) and near occlusions (n = 0), leaving 188 carotid arteries. Intraplaque hemorrhage was detected by using MPRAGE. Calcification, adventitial pattern, stenosis, maximum plaque thickness (total, soft, and hard), ulceration, and intraluminal thrombus on CTA were recorded. Atherosclerosis risk factors and medications were recorded. We used mixed-effects multivariable Poisson regression, accounting for 2 vessels per patient. For the final model, backward elimination was used with a threshold of P < .10. Receiver operating characteristic analysis determined intraplaque hemorrhage by using the area under the curve.
resultsOur final model included the rim sign (prevalence ratio = 11.9, P < .001) and maximum soft-plaque thickness (prevalence ratio = 1.2, P = .06). This model had excellent intraplaque hemorrhage prediction (area under the curve = 0.94), outperforming the rim sign, maximum soft-plaque thickness, NASCET stenosis, and ulceration (area under the curve = 0.88, 0.86, 0.77, and 0.63, respectively; P < .001). Addition of the rim sign performed better than each marker alone, including maximum soft-plaque thickness (area under the curve = 0.94 versus 0.86, P < .001), NASCET stenosis (area under the curve = 0.90 versus 0.77, P < .001), and ulceration (area under the curve = 0.90 versus 0.63, P < .001).
conclusionsThe CTA rim sign of adventitial calcification with internal soft plaque is highly predictive of carotid intraplaque hemorrhage.
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