ArticleAJNR. American journal of neuroradiology2016
Gray Matter Growth Is Accompanied by Increasing Blood Flow and Decreasing Apparent Diffusion Coefficient during Childhood.
Article in AJNR. American journal of neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Measuring Quantitative Cerebral Blood Flow in Healthy Children: A Systematic Review of Neuroimaging Techniques.Journal of magnetic resonance imaging : JMRI · 2024Pooled it
- Clinical utility of Arterial Spin Labeling perfusion images in pediatric neurological emergencies.La Radiologia medica · 2026Review
- Age-stratified multimodal MRI and machine learning to explore autism-related brain characteristics in youth.Frontiers in psychiatry · 2026Article
- Elevated Thalamic Blood Flow in Self-Limited Epilepsy with Centrotemporal Spikes.bioRxiv : the preprint server for biology · 2025Article
- Deep Learning-Based Pediatric Brain Region Segmentation and Volumetric Analysis for General Growth Pattern in Healthy Children.Journal of imaging informatics in medicine · 2025Article
- Children with Congenital Heart Diseases Exhibit Altered Deep Gray Matter Structures.Clinical neuroradiology · 2024Article
- Arterial Spin Labeling for Pediatric Central Nervous System Diseases: Techniques and Clinical Applications.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2023Article
- Age-related topographic map of magnetic resonance diffusion metrics in neonatal brains.Human brain mapping · 2022Article
- Age-dependent Intracranial Artery Morphology in Healthy Children.Clinical neuroradiology · 2022Article
- Food-Approach Eating Behaviors and Brain Morphology: The Generation R Study.Frontiers in nutrition · 2022Article
- Early Onset Diffusion Abnormalities in Refractory Headache Disorders.Frontiers in neurology · 2022Article
- Artificial intelligence for automatic cerebral ventricle segmentation and volume calculation: a clinical tool for the evaluation of pediatric hydrocephalus.Journal of neurosurgery. Pediatrics · 2021Article
- Spatial coefficient of variation applied to arterial spin labeling MRI may contribute to predict surgical revascularization outcomes in pediatric moyamoya vasculopathy.Neuroradiology · 2020Article
- Association of Pediatric Acute-Onset Neuropsychiatric Syndrome With Microstructural Differences in Brain Regions Detected via Diffusion-Weighted Magnetic Resonance Imaging.JAMA network open · 2020Article
- Children with epilepsy demonstrate macro- and microstructural changes in the thalamus, putamen, and amygdala.Neuroradiology · 2020Article
- Microstructural Integrity of the Hippocampus During Childhood: Relations With Age and Source Memory.Frontiers in psychology · 2020Article
- Cerebral volume and diffusion MRI changes in children with sensorineural hearing loss.NeuroImage. Clinical · 2020Article
- Brain Diffusion Abnormalities in Children with Tension-Type and Migraine-Type Headaches.AJNR. American journal of neuroradiology · 2018Article
- Development of sex differences in the human brain.Cognitive neuroscienceArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeNormal values of gray matter volume, cerebral blood flow, and water diffusion have not been established for healthy children. We sought to determine reference values for age-dependent changes of these parameters in healthy children. MATERIALS AND
methodsWe retrospectively reviewed MR imaging data from 100 healthy children. Using an atlas-based approach, age-related normal values for regional CBF, apparent diffusion coefficient, and volume were determined for the cerebral cortex, hippocampus, thalamus, caudate, putamen, globus pallidus, amygdala, and nucleus accumbens.
resultsAll gray matter structures grew rapidly before the age of 10 years and then plateaued or slightly declined thereafter. The ADC of all structures decreased with age, with the most rapid changes occurring prior to the age of 5 years. With the exception of the globus pallidus, CBF increased rather linearly with age.
conclusionsNormal brain gray matter is characterized by rapid early volume growth and increasing CBF with concomitantly decreasing ADC. The extracted reference data that combine CBF and ADC parameters during brain growth may provide a useful resource when assessing pathologic changes in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.