ArticleJournal of nanobiotechnology2016
Exposure to TiO2 nanoparticles increases Staphylococcus aureus infection of HeLa cells.
Article in Journal of nanobiotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metal Nanoparticles in Infection and Immunity.Immunological investigations · 2020Pooled it
- Targeted Drug Delivery Strategies in Overcoming Antimicrobial Resistance: Advances and Future Directions.Pharmaceutics · 2025Review
- Nanoparticle-mediated approaches to combat antibiotic resistance: a comprehensive review on current progress, mechanisms, and future perspectives.RSC advances · 2025Review
- AgrC biotinylation inhibits Staphylococcus aureus infection.PloS one · 2025Article
- Antifungal effect of titanium oxide nanoparticles onFrontiers in cellular and infection microbiology · 2025Article
- Advancements in Nanoparticle-Based Strategies for Enhanced Antibacterial Interventions.Cell biochemistry and biophysics · 2024Review
- Biogenic Synthesis and Characterisation of Novel Potassium Nanoparticles byIndian journal of microbiology · 2024Article
- Alleviation of doxorubicin adverse effects via loading into various drug-delivery systems: a comparative study.Therapeutic delivery · 2024Article
- A novel facile synthesis of metal nitride@metal oxide (BN/GdScientific reports · 2023Article
- Biosynthesis of Peptide Hydrogel-Titania Nanoparticle Composites with Antibacterial Properties.Gels (Basel, Switzerland) · 2023Article
- Peelable Alginate Films Reinforced by Carbon Nanofibers Decorated with Antimicrobial Nanoparticles for Immediate Biological Decontamination of Surfaces.Nanomaterials (Basel, Switzerland) · 2023Article
- Nanoparticle formulations for therapeutic delivery, pathogen imaging and theranostic applications in bacterial infections.Theranostics · 2023Review
- Copper nanocluster composites for analytical (bio)-sensing and imaging: a review.Mikrochimica acta · 2021Review
- Testing Strategies of the In Vitro Micronucleus Assay for the Genotoxicity Assessment of Nanomaterials in BEAS-2B Cells.Nanomaterials (Basel, Switzerland) · 2021Article
- Two-Step Triethylamine-Based Synthesis of MgO Nanoparticles and Their Antibacterial Effect against Pathogenic Bacteria.Nanomaterials (Basel, Switzerland) · 2021Article
- Emerging Strategies to Combat β-Lactamase Producing ESKAPE Pathogens.International journal of molecular sciences · 2020Review
- Exposure to TiONanomaterials (Basel, Switzerland) · 2020Article
- Titanium dioxide nanoparticles exaggerate respiratory syncytial virus-induced airway epithelial barrier dysfunction.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Exposure Route of TiONanomaterials (Basel, Switzerland) · 2020Review
- Nanoparticles as Anti-Microbial, Anti-Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation.Nanomaterials (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTitanium dioxide (TiO2) is one of the most common nanoparticles found in industry ranging from food additives to energy generation. Approximately four million tons of TiO2 particles are produced worldwide each year with approximately 3000 tons being produced in nanoparticulate form, hence exposure to these particles is almost certain.
resultsEven though TiO2 is also used as an anti-bacterial agent in combination with UV, we have found that, in the absence of UV, exposure of HeLa cells to TiO2 nanoparticles significantly increased their risk of bacterial invasion. HeLa cells cultured with 0.1 mg/ml rutile and anatase TiO2 nanoparticles for 24 h prior to exposure to bacteria had 350 and 250 % respectively more bacteria per cell. The increase was attributed to bacterial polysaccharides absorption on TiO2 NPs, increased extracellular LDH, and changes in the mechanical response of the cell membrane. On the other hand, macrophages exposed to TiO2 particles ingested 40 % fewer bacteria, further increasing the risk of infection.
conclusionsIn combination, these two factors raise serious concerns regarding the impact of exposure to TiO2 nanoparticles on the ability of organisms to resist bacterial infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.