ArticleScientific reports2016
Analysis of proteome dynamics inside the silk gland lumen of Bombyx mori.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Silk components and properties of the multilayer cocoon of the greater wax moth, Galleria mellonella.Insect science · 2026Article
- Morphological and compositional basis of silk fiber function inJournal of materials chemistry. B · 2026Article
- Article
- Regionalization of gene expression and cell types in the silk gland of the pantry mothbioRxiv : the preprint server for biology · 2025Article
- Article
- The Silkworm Carboxypeptidase Inhibitor Prevents Gastric Cancer Cells' Proliferation through the EGF/EGFR Signaling Pathway.International journal of molecular sciences · 2023Article
- Effect of cocooning conditions on the structure, carbon and nitrogen isotope ratios of silks.PloS one · 2023Article
- Evaluation and Comparison of the Effects of Mature Silkworm (Iranian journal of pharmaceutical research : IJPR · 2022Article
- Article
- Vaccine for Diabetes-Where Do We Stand?International journal of molecular sciences · 2022Review
- Study of the Antioxidative Effects ofMolecules (Basel, Switzerland) · 2022Article
- Review
- Identification of N-linked Glycoproteins in Silkworm Serum Using Con A Lectin Affinity Chromatography and Mass Spectrometry.Journal of insect science (Online) · 2021Article
- Proteomic Identification ofInternational journal of molecular sciences · 2021Article
- A review on the biological effects of nanomaterials on silkworm (Beilstein journal of nanotechnology · 2021Review
- Let-7 microRNA is a critical regulator in controlling the growth and function of silk gland in the silkworm.RNA biology · 2020Article
- Deep Insight into the Transcriptome of the Single Silk Gland ofInternational journal of molecular sciences · 2019Article
- Silkworm, Bombyx mori, as an alternative model organism in toxicological research.Environmental science and pollution research international · 2018Article
- Wild Silkworm Cocoon Contains More Metabolites Than Domestic Silkworm Cocoon to Improve Its Protection.Journal of insect science (Online) · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The silk gland is the only organ where silk proteins are synthesized and secreted in the silkworm, Bombyx mori. Silk proteins are stored in the lumen of the silk gland for around eight days during the fifth instar. Determining their dynamic changes is helpful for clarifying the secretion mechanism of silk proteins. Here, we identified the proteome in the silk gland lumen using liquid chromatography-tandem mass spectrometry, and demonstrated its changes during two key stages. From day 5 of the fifth instar to day 1 of wandering, the abundances of fibroins, sericins, seroins, and proteins of unknown functions increased significantly in different compartments of the silk gland lumen. As a result, these accumulated proteins constituted the major cocoon components. In contrast, the abundances of enzymes and extracellular matrix proteins decreased in the silk gland lumen, suggesting that they were not the structural constituents of silk. Twenty-five enzymes may be involved in the regulation of hormone metabolism for proper silk gland function. In addition, the metabolism of other non-proteinous components such as chitin and pigment were also discussed in this study.
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