ReviewTherapeutic advances in cardiovascular disease2016
Vascular ageing and interventions: lessons and learnings.
Review in Therapeutic advances in cardiovascular disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Determinants of systemic hypertension in older adults in Africa: a systematic review.BMC cardiovascular disorders · 2019Pooled it
- Beyond medication: factors contributing to uncontrolled hypertension from the 2023 Indonesian health survey.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Prevalence, risks factors, and control of hypertension in Guinean older adults in 2021: a cross-sectional survey.BMC public health · 2024Article
- Age and vascular aging: an unexplored frontier.Frontiers in cardiovascular medicine · 2023Review
- Diabetes, hypertension, and cardiovascular disease development.Journal of translational medicine · 2022Article
- Multilevel modeling, prevalence, and predictors of hypertension in Ghana: Evidence from Wave 2 of the World Health Organization's Study on global AGEing and adult health.Health science reports · 2021Article
- The impact of age and 24-h blood pressure on arterial health in acute ischemic stroke patients: The Norwegian stroke in the young study.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Role of GDF-15, YKL-40 and MMP 9 in patients with end-stage kidney disease: focus on sex-specific associations with vascular outcomes and all-cause mortality.Biology of sex differences · 2021Article
- Prevalence and factors associated with hypertension among people living with HIV/AIDS on antiretroviral therapy in Uganda.The Pan African medical journal · 2021Article
- Two-dimensional system based on organic and functional impairment with aging for precisely assessing risk factors in chronic disease.Archives of medical science : AMS · 2020Article
- Target Organ Damage and Cardiovascular Risk in a Hypertensive Roma Sample Population in Romania.Maedica · 2018Article
- Arterial ageing: from the shadows to centre stage in cardiovascular medicine.European heart journal supplements : journal of the European Society of Cardiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
This review discusses the relationship between elevated blood pressure, hypertension, arterial stiffness and hence vascular ageing. This is a complex process and the majority of treatments target the consequences of this, rather than the pathophysiology of ageing itself. This is because preventing vascular ageing from occurring is complex and would require very early intervention and lifelong treatment. The process of arteriosclerosis is known to result from reversible and irreversible functional components, and, together, these are responsible for the increased systolic and decreased diastolic blood pressure seen with advancing age. Indeed, hypertension develops as it becomes more difficult for the heart to drive blood flow around the body, as a result of poor ventricular coupling and increased arterial stiffness. Elevated blood pressure is therefore a clinical manifestation of ageing that continues to increase with advancing years, and is also linked with an increased risk of cardiac, cerebrovascular and chronic kidney disease. These manifestations arise due to changing haemodynamics associated with ageing, and therefore treatments that reduce the development of these conditions or delay their progression have the potential to improve patient outcomes. This may be possible with existing therapies as well as new treatments currently under investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.