Evidence map›Paper›PMID 27101944›Full record

ArticleInternational journal of cancer2016

Nevus count associations with pigmentary phenotype, histopathological melanoma characteristics and survival from melanoma.

Nicholas J Taylor, Nancy E Thomas, Hoda Anton-Culver, Bruce K Armstrong, Colin B Begg, Klaus J Busam, Anne E Cust, Terence Dwyer, Lynn From, Richard P Gallagher and 9 more

Abstract read
In one paragraph

Article in International journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Nicholas J TaylorDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
Nancy E ThomasDepartment of Dermatology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC.
Hoda Anton-CulverDepartment of Epidemiology, University of California, Irvine, CA.
Bruce K ArmstrongSchool of Public Health, University of Sydney, Sydney, NSW, Australia.
Colin B BeggDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
Klaus J BusamDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.
Anne E CustSchool of Public Health, University of Sydney, Sydney, NSW, Australia.
Terence DwyerGeorge Institute for Global Health Research, University of Oxford, Oxford, United Kingdom.
Lynn FromWomen's College Hospital, Toronto, ON, Canada.
Richard P GallagherBritish Columbia Cancer Research Centre, Vancouver, BC, Canada.
Stephen B GruberKeck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA.
Diane E NishriCancercare Ontario, Toronto, ON, Canada.
Irene OrlowDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
Stefano RossoPiedmont Tumor Registry, Turin, Italy.
Alison J VennMenzies Centre for Population Health, University of Tasmania, Hobart, Tasmania, Australia.
Roberto ZanettiPiedmont Tumor Registry, Turin, Italy.
Marianne BerwickDepartments of Internal Medicine and Dermatology, University of New Mexico, Albuquerque, NM.
Peter A KanetskyDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
GEM Study Group

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Melanoma RAS/BRAF Mutation:Heterogeneity-Risk-PrognosisR01CA112243 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI THOMAS, NANCY E. · 2005 to 2014
$5.4M
A MODEL FOR GENETIC SUSCEPTIBILITY: MELANOMAU01CA083180 · NCI · UNIVERSITY OF NEW MEXICO · PI BERWICK, MARIANNE · 1999 to 2003
$5.2M
Solar Exposure and Melanoma SurvivalR01CA112524 · NCI · UNIVERSITY OF NEW MEXICO · PI BERWICK, MARIANNE · 2005 to 2009
$2.5M
Molecular Epidemiology of MelanomaR01CA092428 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KANETSKY, PETER A · 2002 to 2006
$2.3M
Moffitt Postdoctoral Training Program in Molecular & Genetic EpidemiologyR25CA147832 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI EGAN, KATHLEEN M. · 2010 to 2014
$2.0M
Epidemiologic Parameters of Rare Cancer Risk FactorsR01CA098438 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI BEGG, COLIN B · 2003 to 2005
$839k
Moffitt Postdoctoral Training Program in Molecular EpidemiologyT32CA147832 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI KANETSKY, PETER A · 2015 to 2019
$659k
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA092428NCI NIH HHS R01 CA098438NCI NIH HHS R01 CA112243NCI NIH HHS R01 CA112524NCI NIH HHS R25 CA147832NCI NIH HHS T32 CA147832NCI NIH HHS U01 CA083180NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

Although nevus count is an established risk factor for melanoma, relationships between nevus number and patient and tumor characteristics have not been well studied and the influence of nevus count on melanoma-specific survival is equivocal. Using data from the Genes, Environment and Melanoma (GEM) study, a large population-based study of primary cutaneous melanoma, we evaluated associations between number of nevi and patient features, including sun-sensitivity summarized in a phenotypic index, and tumor characteristics. We also assessed the association of nevus count with melanoma-specific survival. Higher nevus counts were independently and positively associated with male gender and younger age at diagnosis, and they were inversely associated with lentigo maligna histology. We observed a borderline significant trend of poorer melanoma-specific survival with increasing quartile of nevus count, but little or no association between number of nevi and pigmentary phenotypic characteristics or prognostic tumor features.

Indexed as

PhenotypeAdultAgedCase-Control StudiesCutaneous Malignant MelanomaFemaleHumansKaplan-Meier EstimateMaleMelanomaMiddle AgedNevus, PigmentedOdds RatioPopulation SurveillancePrognosisProportional Hazards Modelsdisease-specific survivalmelanomaneviphenotypic characteristics

Identifiers

PMID27101944
PMCPMC4939099

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.