ArticleScientific reports2016
Lifecourse socioeconomic status and type 2 diabetes: the role of chronic inflammation in the English Longitudinal Study of Ageing.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
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- Behavioural and metabolic mediators of socioeconomic inequalities in type 2 diabetes: comparing counterfactual and traditional mediation analysis.European journal of public health · 2025Article
- Social determinants of health and type 2 diabetes in Asia.Journal of diabetes investigation · 2025Review
- Lifetime employment trajectories and cancer.Scientific reports · 2024Article
- Exploring the gender difference in type 2 diabetes incidence in a Swiss cohort using latent class analysis: an intersectional approach.BMJ public health · 2024Article
- Lifetime Employment Trajectories and Cancer: A Population-Based Cohort Study.Research square · 2024Article
- Association between Relative Thrombocytosis and Microalbuminuria in Adults with Mild Fasting Hyperglycemia.Journal of personalized medicine · 2024Article
- Distinct domains of childhood disadvantage and cognitive performance among older Brazilians: Evidence from ELSI-Brazil.SSM - population health · 2023Article
- Association of urinary prostaglandin E2 metabolite and mortality among adults.Scientific reports · 2022Article
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- Diabetes Mellitus and Associated Factors in Slovakia: Results from the European Health Interview Survey 2009, 2014, and 2019.Nutrients · 2021Article
- Diabetes and associated dietary intake among urban adults: COPEN (Colombian Nutritional Profiles)-a cross-sectional study.BMJ open · 2021Article
- Mediterranean Diet and White Blood Cell Count-A Randomized Controlled Trial.Foods (Basel, Switzerland) · 2021Article
- Does symptomatic knee osteoarthritis increase the risk of all-cause mortality? Data from four international population-based longitudinal surveys of aging.Clinical rheumatology · 2019Article
- Discovering markers of healthy aging: a prospective study in a Danish male birth cohort.Aging · 2019Article
- Epigenome-wide DNA methylation in placentas from preterm infants: association with maternal socioeconomic status.Epigenetics · 2019Article
- Association between regional deprivation and type 2 diabetes incidence in Germany.BMJ open diabetes research & care · 2019Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
We examined the association between lifecourse socioeconomic status (SES) and the risk of type 2 diabetes at older ages, ascertaining the extent to which adult lifestyle factors and systemic inflammation explain this relationship. Data were drawn from the English Longitudinal Study of Ageing (ELSA) which, established in 2002, is a representative cohort study of ≥50-year olds individuals living in England. SES indicators were paternal social class, participants' education, participants' wealth, and a lifecourse socioeconomic index. Inflammatory markers (C-reactive protein and fibrinogen) and lifestyle factors were measured repeatedly; diabetes incidence (new cases) was monitored over 7.5 years of follow-up. Of the 6218 individuals free from diabetes at baseline (44% women, mean aged 66 years), 423 developed diabetes during follow-up. Relative to the most advantaged people, those in the lowest lifecourse SES group experienced more than double the risk of diabetes (hazard ratio 2.59; 95% Confidence Interval (CI) = 1.81-3.71). Lifestyle factors explained 52% (95%CI:30-85) and inflammatory markers 22% (95%CI:13-37) of this gradient. Similar results were apparent with the separate SES indicators. In a general population sample, socioeconomic inequalities in the risk of type 2 diabetes extend to older ages and appear to partially originate from socioeconomic variations in modifiable factors which include lifestyle and inflammation.
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