Evidence map›Paper›PMID 27101869›Full record

ArticleAnnals of clinical microbiology and antimicrobials2016

Enhancing pathogen identification in patients with meningitis and a negative Gram stain using the BioFire FilmArray(®) Meningitis/Encephalitis panel.

Susan H Wootton, Elizabeth Aguilera, Lucrecia Salazar, Andrew C Hemmert, Rodrigo Hasbun

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical microbiology and antimicrobials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Molecular Diagnosis of Bacterial Meningitis in Ethiopia: A Narrative Review of Current Evidence and Implementation Gaps.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Review
  2. Article
  3. Article
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  6. A multicenter evaluation of the QIAstat-Dx meningitis-encephalitis syndromic test kit as compared to the conventional diagnostic microbiology workflow.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Clinical Performance of FilmArray Meningitis/Encephalitis Multiplex Polymerase Chain Reaction Panel in Central Nervous System Infections.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022
    Article
  12. Article
  13. Impact of cerebrospinal fluid syndromic testing in the management of children with suspected central nervous system infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Article
  14. Review
  15. Review
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  19. [Meningitis/Encephalitis diagnosis in ICU using Multiplex PCR system: Is it time of change?]Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2019
    Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Susan H WoottonDivision of Infectious Diseases, Department of Pediatrics, University of Texas (UT) Health Science Center, Houston, TX, 77030, USA.
Elizabeth AguileraDivision of Infectious Diseases, Department of Pediatrics, University of Texas (UT) Health Science Center, Houston, TX, 77030, USA.
Lucrecia SalazarDivision of Infectious Diseases, Department of Internal Medicine, University of Texas (UT) Health Science Center, 6431 Fannin St. 2.112 MSB, Houston, TX, 77030, USA.
Andrew C HemmertBioFire Diagnostics, LLC, Salt Lake City, 84108, USA.
Rodrigo HasbunDivision of Infectious Diseases, Department of Internal Medicine, University of Texas (UT) Health Science Center, 6431 Fannin St. 2.112 MSB, Houston, TX, 77030, USA. Rodrigo.Hasbun@uth.tmc.edu.

Funding

NCRR NIH HHS 1 K23 RR01892901A2
6 · The paper itself

Abstract

backgroundMeningitis with a negative cerebrospinal (CSF) Gram stain represents a diagnostic and therapeutic challenge. The purpose of our study was to evaluate the performance of the BioFire FilmArray(®) Meningitis/Encephalitis (FA ME) panel in patients presenting with community-acquired meningitis with a negative Gram stain.

methodsCSF from 48 patients with community-acquired meningitis with a negative Gram stain admitted to four hospitals in Houston, TX underwent additional testing by the FA ME. FA ME results were compared to results obtained as part of routine evaluation.

resultsThe panel detected pathogens not previously identified in 11 (22.9 %) of 48, but did not detect pathogens identified by standard technique (West Nile virus, Histoplasma) in 5 (15.2 %) patients.

conclusionsRapid testing for the most common pathogens causing meningitis will aid in the diagnosis and treatment of patients with meningitis.

Indexed as

AdolescentAdultAgedAged, 80 and overBacteriaChildChild, PreschoolCommunity-Acquired InfectionsEncephalitisFemaleGentian VioletHumansInfantMaleMeningitisMiddle AgedGentian VioletGram's stainPhenazinesAseptic meningitisEncephalitisMolecular diagnostic techniquesPolymerase chain reaction

Identifiers

PMID27101869
PMCPMC4839114

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.