ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2017
Is Cancer Protective for Subsequent Alzheimer's Disease Risk? Evidence From the Utah Population Database.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Association Between Alzheimer Disease and Cancer With Evaluation of Study Biases: A Systematic Review and Meta-analysis.JAMA network open · 2020Pooled it
- Associations Between Malignant Tumors and Alzheimer's Disease: A Cross-Sectional Study.Brain and behavior · 2025Article
- The inverse association between cancer history and incident cognitive impairment: Addressing attrition bias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Article
- Lower Incidence of Dementia Following Cancer Diagnoses: Evidence from a Large Cohort and Mendelian Randomization Study.The journal of prevention of Alzheimer's disease · 2024Article
- Risk of All-Cause Dementia, Alzheimer Disease, and Vascular Dementia in Breast Cancer Survivors: A Longitudinal Register-Based Study.Neurology. Clinical practice · 2023Article
- A Systematic Review on the Potential Acceleration of Neurocognitive Aging in Older Cancer Survivors.Cancers · 2023Review
- Article
- Comorbidity and Cancer Disease Rates among Those at High-Risk for Alzheimer's Disease: A Population Database Analysis.International journal of environmental research and public health · 2022Article
- Investigating the association between cancer and dementia risk: a longitudinal cohort study.Alzheimer's research & therapy · 2022Article
- Cancer diagnosis is associated with a lower burden of dementia and less Alzheimer's-type neuropathology.Brain : a journal of neurology · 2022Article
- Autoencoder Networks Decipher the Association between Lung Cancer and Alzheimer's Disease.Computational intelligence and neuroscience · 2022Article
- Investigating the association between cancer and the risk of dementia: Results from the Memento cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Bladder Cancer Immunotherapy by BCG Is Associated with a Significantly Reduced Risk of Alzheimer's Disease and Parkinson's Disease.Vaccines · 2021Article
- Cancer and risk of Alzheimer's disease: Small association in a nationwide cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- Family Study Designs Informed by Tumor Heterogeneity and Multi-Cancer Pleiotropies: The Power of the Utah Population Database.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Evidence of a Causal Association Between Cancer and Alzheimer's Disease: a Mendelian Randomization Analysis.Scientific reports · 2019Article
- Later-Life Trajectories of Cognitive Functioning among Married and Widowed Older Men and Women of Mexican Origin.Journal of cross-cultural gerontology · 2019Article
- Candidate Genes and MiRNAs Linked to the Inverse Relationship Between Cancer and Alzheimer's Disease: Insights From Data Mining and Enrichment Analysis.Frontiers in genetics · 2019Article
- Relationship of Cancer to Brain Aging Markers of Alzheimer's Disease: The Framingham Heart Study.Advances in geriatric medicine and research · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveSeveral studies have suggested that cancer is associated with a reduced risk of the development of Alzheimer's disease (AD). This study seeks to improve our understanding of the association between cancer and the development of AD by showing how mortality selection alters this relationship.
methodA retrospective cohort study was carried out examining 92,425 individuals (47,873 women and 44,552 men) from the Utah Population Database with and without a history of any primary cancer identified by the Utah Cancer Registry. All individuals were aged 65-79 years and free of dementia in 1992 and followed for upwards of 18 years (1992-2009) for AD ascertainment, which was identified using diagnostic information from Medicare claims data.
resultsWe replicate previous results suggesting that cancer is associated with reduced risk of subsequent AD under specific statistical model specifications. However, these results should not be interpreted as evidence of an etiological association. We conclude that higher rates of overall mortality among individuals with cancer relative to those without cancer induce the widely reported putative protective association with cancer.
conclusionCareful consideration of model specification and the profound effects of mortality selection in the older adult population is essential when investigating the relationship between aging-related diseases such as cancer and AD. We show that cancer does not provide protection from AD as previously described in the literature. Social scientists seeking to understand social disparities in disease outcomes among older adults may therefore want to strongly consider the role of mortality selection which, if uncorrected, may generate biased associations.
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