Evidence map›Paper›PMID 27101419›Full record

ReviewSmall (Weinheim an der Bergstrasse, Germany)2016

Advancing Tissue Engineering: A Tale of Nano-, Micro-, and Macroscale Integration.

Jeroen Leijten, Jeroen Rouwkema, Yu Shrike Zhang, Amir Nasajpour, Mehmet Remzi Dokmeci, Ali Khademhosseini

Open access · bronzeAbstract readReview
In one paragraph

Review in Small (Weinheim an der Bergstrasse, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 74 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Polymeric microcarriers for minimally-invasive cell delivery.Frontiers in bioengineering and biotechnology · 2023
    Review
  9. Article
  10. Everything You Always Wanted to Know About Organoid-Based Models (and Never Dared to Ask).Cellular and molecular gastroenterology and hepatology · 2022
    Review
  11. Article
  12. 3D Bioprinting of Human Tissues: Biofabrication, Bioinks, and Bioreactors.International journal of molecular sciences · 2021
    Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Cell Printing in Complex Hydrogel Scaffolds.IEEE transactions on nanobioscience · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 4 countries.

Jeroen LeijtenHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Jeroen RouwkemaHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Yu Shrike ZhangHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Amir NasajpourHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Mehmet Remzi DokmeciHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Ali KhademhosseiniHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Brigham and Women's Hospital · USHarvard–MIT Division of Health Sciences and Technology · USInnovation Research Center · USKing Abdulaziz University · SAMassachusetts Institute of Technology · US

Funding

Microengineered Osteons for Bone Tissue EngineeringR01AR057837 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YANG, YUNZHI · 2010 to 2018
$5.1M
3D combinatorial microenvironments for effective cell based therapyR01HL099073 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI, LIAO, RONGLIH · 2010 to 2013
$2.6M
Engineering Vascularized Bone Tissues By Microfabrication And ScaffoldingR01DE021468 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YANG, YUNZHI · 2011 to 2014
$1.8M
A Microfabrication Platform for Direct Printing Vascularized Functional Tissue CoR01EB012597 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN · 2010 to 2013
$1.4M
Microengineered Osteoinductive and Vasculogenic ScaffoldR56AR063745 · NIAMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI JABBARI, ESMAIEL · 2013 to 2014
$669k
A miniaturized model of human skin and lymph node for drug discovery and testingR56AI105024 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI · 2014 to 2014
$442k
NHLBI NIH HHS HL099073NHLBI NIH HHS R01 HL099073NIAID NIH HHS AI105024NIAID NIH HHS R56 AI105024NIAMS NIH HHS AR057837NIAMS NIH HHS AR063745NIAMS NIH HHS R01 AR057837NIAMS NIH HHS R56 AR063745NIBIB NIH HHS EB012597NIBIB NIH HHS R01 EB012597NIDCR NIH HHS DE021468NIDCR NIH HHS R01 DE021468
6 · The paper itself

Abstract

Tissue engineering has the potential to revolutionize the health care industry. Delivering on this promise requires the generation of efficient, controllable and predictable implants. The integration of nano- and microtechnologies into macroscale regenerative biomaterials plays an essential role in the generation of such implants, by enabling spatiotemporal control of the cellular microenvironment. Here we review the role, function and progress of a wide range of nano- and microtechnologies that are driving the advancements in the field of tissue engineering.

Indexed as

Biocompatible MaterialsBiotinCellular MicroenvironmentDNAGelsHumansHydrogelsKineticsMicrofluidicsMicroscopy, Electron, ScanningNanotechnologyPlatelet-Derived Growth FactorRegenerationStatic ElectricityStreptavidinTemperatureBiocompatible MaterialsBiotinDNAGelsHydrogelsPlatelet-Derived Growth FactorStreptavidinVascular Endothelial Growth Factor Abiomimeticsmicroenvironmentsmicrofluidicsmicromaterialstissue engineering

Identifiers

PMID27101419
PMCPMC4895865
OpenAlexW2188057713

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.