Trial reportPloS one2016
Agreement between Patient and Proxy Assessments of Quality of Life among Older Adults with Vascular Cognitive Impairment Using the EQ-5D-3L and ICECAP-O.
Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Exercise on Cognition and Function in Seniors With Vascular Cognitive Impairment: A Randomized Controlled Trial
COVID-19 - Quality of Life After Infection
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- ICECAP-O, the current state of play: a systematic review of studies reporting the psychometric properties and use of the instrument over the decade since its publication.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Pooled it
- A Review of the Application of Generic Preference-Based Instruments with Older People Across Care Settings.Applied health economics and health policy · 2026Review
- Uses of the ICECAP measure of capability in adults with neurological health conditions: a scoping review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Article
- Examining interrater agreement between self-report and proxy-report responses for the quality of life-aged care consumers (QOL-ACC) instrument.Journal of patient-reported outcomes · 2024Article
- Can Proxy Ratings Supplement Patient Report to Assess Functional Domains Among Hospitalized Patients?Archives of physical medicine and rehabilitation · 2022Article
- Capability instruments in economic evaluations of health-related interventions: a comparative review of the literature.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Review
- Assessing the proxy response bias of EQ-5D-3 L in general population: a study based on a large-scale representative household health survey using propensity score matching.Health and quality of life outcomes · 2020Article
- The combined impact of dependency on caregivers, disability, and coping strategy on quality of life after ischemic stroke.Health and quality of life outcomes · 2019Article
- Decline in Instrumental Activities of Daily Living over 4-Year: The Association with Hearing, Visual and Dual Sensory Impairments among Non-Institutionalized Women.The journal of nutrition, health & aging · 2019Article
- Emotional Distress of Patients at End-of-Life and Their Caregivers: Interrelation and Predictors.Frontiers in psychology · 2018Article
- Validation of the Spanish Version of the ICECAP-O for Nursing Home Residents with Dementia.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundThe assessment of quality of life is critical in ascertaining the benefit of interventions aimed to reduce morbidity among individuals with cognitive impairment. However, the assessment of quality of life is challenging in this population due to the uncertain validity of patient responses as cognitive function declines. Hence, we examined the level of agreement between patient and proxy assessments of health related quality of life (HRQoL) and wellbeing based on the domains that comprise each of these constructs.
methodsAnalysis of baseline data from 71 community-dwelling older adults with mild Vascular Cognitive Impairment (VCI) who participated in a six-month proof-of-concept single-blinded randomized trial. Level of agreement between patient and caregiver ratings of HRQoL (EQ-5D-3L) and wellbeing (ICECAP-O) were compared using raw agreement (%), intraclass correlation coefficient (ICC) and weighted Cohen's kappa statistic.
resultsSelf-care (assessed via the EQ-5D-3L) demonstrated almost perfect raw agreement between the patient and caregiver ratings. Three domains (mobility, pain and anxiety) of the EQ-5D-3L demonstrated fair agreement between the patient and caregiver ratings. Two (attachment and control) of the five ICECAP-O domains demonstrated slight agreement. The ICC indicated good agreement for the EQ-5D-3L and poor agreement for the ICECAP-O.
conclusionThere is better patient-proxy agreement for the EQ-5D-3L compared with the ICECAP-O among individuals with mild VCI. These findings imply that the ICECAP-O may have limited clinical, research and policy related utility among individuals with mild VCI.
trial registrationClinicalTrials.gov NCT01027858.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.