ReviewPLoS pathogens2016
Diplomatic Assistance: Can Helminth-Modulated Macrophages Act as Treatment for Inflammatory Disease?
Review in PLoS pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Plasma-activated gas: a new dawn for wound care and infection.Medical gas research · 2026Review
- Protection of mice against septic shock induced by lethal intraperitoneal dose of LPS by a recombinantMicrobiology spectrum · 2026Article
- Type I Cystatin Derived fromMicroorganisms · 2024Article
- Association between helminth infection and allergic disorders among children in Batu, Ethiopia.Immunity, inflammation and disease · 2024Article
- Therapeutic effect of Echinococcus granulosus cyst fluid on bacterial sepsis in mice.Parasites & vectors · 2023Article
- Immunomodulatory effects of chronic trichinellosis onPathogens and global health · 2023Article
- Bone erosion in inflammatory arthritis is attenuated byiScience · 2022Article
- Host Immune Response to Clinical HypervirulentJournal of immunology research · 2022Article
- Parasite worm antigens instruct macrophages to release immunoregulatory extracellular vesicles.Journal of extracellular vesicles · 2021Article
- Fasciola hepatica hijacks host macrophage miRNA machinery to modulate early innate immune responses.Scientific reports · 2021Article
- Nrf2 Participates in M2 Polarization byFrontiers in immunology · 2021Article
- Excretory/Secretory Products FromFrontiers in immunology · 2020Article
- Adoptive transfer of Trichinella spiralis-activated macrophages can ameliorate both Th1- and Th2-activated inflammation in murine models.Scientific reports · 2019Article
- Intraperitoneal administration of the anti-IL-23 antibody prevents the establishment of intestinal nematodes in mice.Scientific reports · 2018Article
- Immunoproteomics and Surfaceomics of the Adult TapewormFrontiers in immunology · 2018Article
- Opening a Can of Worms: Leprosy Reactions and Complicit Soil-Transmitted Helminths.EBioMedicine · 2017Article
- Review
- Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response.Frontiers in cellular and infection microbiology · 2017Article
- Helminth Immunomodulation in Autoimmune Disease.Frontiers in immunology · 2017Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helminths have evolved numerous pathways to prevent their expulsion or elimination from the host to ensure long-term survival. During infection, they target numerous host cells, including macrophages, to induce an alternatively activated phenotype, which aids elimination of infection, tissue repair, and wound healing. Multiple animal-based studies have demonstrated a significant reduction or complete reversal of disease by helminth infection, treatment with helminth products, or helminth-modulated macrophages in models of allergy, autoimmunity, and sepsis. Experimental studies of macrophage and helminth therapies are being translated into clinical benefits for patients undergoing transplantation and those with multiple sclerosis. Thus, helminths or helminth-modulated macrophages present great possibilities as therapeutic applications for inflammatory diseases in humans. Macrophage-based helminth therapies and the underlying mechanisms of their therapeutic or curative effects represent an under-researched area with the potential to open new avenues of treatment. This review explores the application of helminth-modulated macrophages as a new therapy for inflammatory diseases.
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Registered trials
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