ArticleMolecular and cellular biology1989
Structural organization of upstream exons and distribution of transcription start sites in the chicken c-myb gene.
Article in Molecular and cellular biology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- The interaction between the Spt6-tSH2 domain and Rpb1 affects multiple functions of RNA Polymerase II.Nucleic acids research · 2022Article
- Minimal truncation of the c-myb gene product in rapid-onset B-cell lymphoma.Journal of virology · 1997Article
- Activation of the c-myb locus is insufficient for the rapid induction of disseminated avian B-cell lymphoma.Journal of virology · 1992Article
- Structure and biological activity of the transcriptional initiation sequences of the murine c-myb oncogene.Nucleic acids research · 1989Article
- Hematopoietic lineage-specific heterogeneity in the 5'-terminal region of the chicken proto-myb transcript.Molecular and cellular biology · 1989Article
- Transcription of the chicken myb proto-oncogene starts within a CpG island.Nucleic acids research · 1989Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We mapped and sequenced three upstream exons of the chicken c-myb gene and the regions flanking the first coding exon. We found multiple potential binding sites for transcription factors in the 5'-noncoding region, a T-rich stretch of 78 base pairs (bp) (68% T) in the first intron, and four fairly long open reading frames in the antisense direction of the first coding exon and its flanking regions. Three major transcription start sites, contained within a single 11-bp region, were identified by S1 nuclease analysis and primer extension. A sequence comparison of the avian and murine c-myb genes revealed a highly conserved sequence of 124 bp in the 5'-noncoding region. Its location between the putative transcription factor binding sites and the major transcription start sites suggests that it may play an important regulatory role in c-myb expression.
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Registered trials
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