Evidence map›Paper›PMID 27101205›Full record

ArticleBiomaterials2016

Glypican-1 nanoliposomes for potentiating growth factor activity in therapeutic angiogenesis.

Anthony J Monteforte, Brian Lam, Subhamoy Das, Somshuvra Mukhopadhyay, Catherine S Wright, Patricia E Martin, Andrew K Dunn, Aaron B Baker

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
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  3. Review
  4. Review
  5. Article
  6. Biomimetic strategies for the deputization of proteoglycan functions.Frontiers in cell and developmental biology · 2024
    Review
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  8. Endothelial glycocalyx in retina, hyperglycemia, and diabetic retinopathy.American journal of physiology. Cell physiology · 2023
    Review
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  14. Review
  15. Biomimetic Hydrogels to Promote Wound Healing.Frontiers in bioengineering and biotechnology · 2021
    Review
  16. Article
  17. Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Anthony J MonteforteDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA.
Brian LamDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA.
Subhamoy DasDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA.
Somshuvra MukhopadhyayDivision of Pharmacology & Toxicology, University of Texas at Austin, Austin, TX, USA; Institute for Neuroscience, University of Texas at Austin, Austin, TX, USA; Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA.
Catherine S WrightDiabetes Research Group, Department of Life Sciences and Institute for Applied Health Research, Glasgow Caledonian University, Glasgow G4 0BA, UK.
Patricia E MartinDiabetes Research Group, Department of Life Sciences and Institute for Applied Health Research, Glasgow Caledonian University, Glasgow G4 0BA, UK.
Andrew K DunnDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA.
Aaron B BakerDepartment of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA; Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA; The Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin, TX, USA; Institute for Biomaterials, Drug Delivery and Regenerative Medicine, University of Texas at Austin, Austin, TX, USA. Electronic address: abbaker@austin.utexas.edu.
The University of Texas at Austin · USGlasgow Caledonian University · GB

Funding

Optical Imaging of Baseline Blood Flow and Oxygenation During StrokeR01EB011556 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI DUNN, ANDREW K · 2010 to 2018
$3.1M
Engineering Effective Revascularization Strategies for Ischemia in Disease StatesDP2OD008716 · OD · UNIVERSITY OF TEXAS AT AUSTIN · PI BAKER, AARON BLAIR · 2011 to 2011
$2.3M
Microscale Oxygenation Mapping During StrokeR01NS082518 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI DUNN, ANDREW K · 2013 to 2017
$1.7M
Neurovascular Mechanisms of Time-Dependencies in Stroke RehabilitationR01NS078791 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI DUNN, ANDREW K, JONES, THERESA A · 2012 to 2016
$1.7M
Role of Mechanisms of Efflux in Manganese Homeostasis and DetoxificationR00ES020844 · NIEHS · UNIVERSITY OF TEXAS AT AUSTIN · PI MUKHOPADHYAY, SOMSHUVRA · 2013 to 2015
$747k
NIBIB NIH HHS R01 EB011556NIEHS NIH HHS R00 ES020844NIH HHS DP2 OD008716NINDS NIH HHS R01 NS078791NINDS NIH HHS R01 NS082518
6 · The paper itself

Abstract

Therapeutic angiogenesis is a highly appealing concept for treating tissues that become ischemic due to vascular disease. A major barrier to the clinical translation of angiogenic therapies is that the patients that are in the greatest need of these treatments often have long term disease states and co-morbidities, such as diabetes and obesity, that make them resistant to angiogenic stimuli. In this study, we identified that human patients with type 2 diabetes have reduced levels of glypican-1 in the blood vessels of their skin. The lack of this key co-receptor in the tissue may make the application of exogenous angiogenic growth factors or cell therapies ineffective. We created a novel therapeutic enhancer for growth factor activity consisting of glypican-1 delivered in a nanoliposomal carrier (a "glypisome"). Here, we demonstrate that glypisomes enhance FGF-2 mediated endothelial cell proliferation, migration and tube formation. In addition, glypisomes enhance FGF-2 trafficking by increasing both uptake and endosomal processing. We encapsulated FGF-2 or FGF-2 with glypisomes in alginate beads and used these to deliver localized growth factor therapy in a murine hind limb ischemia model. Co-delivery of glypisomes with FGF-2 markedly increased the recovery of perfusion and vessel formation in ischemic hind limbs of wild type and diabetic mice in comparison to mice treated with FGF-2 alone. Together, our findings support that glypisomes are effective means for enhancing growth factor activity and may improve the response to local angiogenic growth factor therapies for ischemia.

Indexed as

AlginatesAnimalsBlood VesselsCell MovementCell ProliferationDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Drug Delivery SystemsEndosomesFibroblast Growth Factor 2Glucuronic AcidGlypicansHEK293 CellsHeLa CellsHexuronic AcidsHindlimbAlginatesFibroblast Growth Factor 2Glucuronic AcidGlypicansHexuronic AcidsLiposomesProto-Oncogene Proteins c-aktVascular Endothelial Growth Factor AAngiogenesisFibroblast growth factor-2 (FGF-2)Glypican-1IschemiaNeovascularizationPeripheral arterial diseaseProteoliposomesVascular endothelial growth factor (VEGF)

Identifiers

PMID27101205
PMCPMC5600893
OpenAlexW2312321428

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.