ArticlePloS one2016
The Low Energy-Coupling Respiration in Zymomonas mobilis Accelerates Flux in the Entner-Doudoroff Pathway.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Eminent Antimicrobial Peptide Resistance inAntibiotics (Basel, Switzerland) · 2024Article
- Better off breathing: an explanation for the seemingly detrimental impact of aerobic respiration onmBio · 2024Article
- Metabolic regulation boosts bioelectricity generation in Zymomonas mobilis microbial fuel cell, surpassing ethanol production.Scientific reports · 2023Article
- Deciphering Molecular Mechanism Underlying Self-Flocculation of Zymomonas mobilis for Robust Production.Applied and environmental microbiology · 2022Article
- Zymomonas mobilis as an emerging biotechnological chassis for the production of industrially relevant compounds.Bioresources and bioprocessing · 2021Review
- Ethanologenesis and respiration in a pyruvate decarboxylase-deficient Zymomonas mobilis.BMC research notes · 2021Article
- The Ethanologenic Bacterium Zymomonas mobilis Divides Asymmetrically and Exhibits Heterogeneity in DNA Content.Applied and environmental microbiology · 2021Article
- Metabolic Profiling of Glucose-Fed Metabolically Active RestingMetabolites · 2020Article
- Cell Aggregation and Aerobic Respiration Are Important forApplied and environmental microbiology · 2019Article
- Improvement of Acetaldehyde Production inFrontiers in microbiology · 2019Article
- Metabolic Engineering of Bacterial Respiration: High vs. Low P/O and the Case ofFrontiers in bioengineering and biotechnology · 2019Review
- Genome Wide Phosphoproteome Analysis ofFrontiers in microbiology · 2019Article
- Aerobic catabolism and respiratory lactate bypass in Ndh-negativeMetabolic engineering communications · 2018Article
- Zymomonas mobilis as a model system for production of biofuels and biochemicals.Microbial biotechnology · 2016Review
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Performing oxidative phosphorylation is the primary role of respiratory chain both in bacteria and eukaryotes. Yet, the branched respiratory chains of prokaryotes contain alternative, low energy-coupling electron pathways, which serve for functions other than oxidative ATP generation (like those of respiratory protection, adaptation to low-oxygen media, redox balancing, etc.), some of which are still poorly understood. We here demonstrate that withdrawal of reducing equivalents by the energetically uncoupled respiratory chain of the bacterium Zymomonas mobilis accelerates its fermentative catabolism, increasing the glucose consumption rate. This is in contrast to what has been observed in other respiring bacteria and yeast. This effect takes place after air is introduced to glucose-consuming anaerobic cell suspension, and can be simulated using a kinetic model of the Entner-Doudoroff pathway in combination with a simple net reaction of NADH oxidation that does not involve oxidative phosphorylation. Although aeration hampers batch growth of respiring Z. mobilis culture due to accumulation of toxic byproducts, nevertheless under non-growing conditions respiration is shown to confer an adaptive advantage for the wild type over the non-respiring Ndh knock-out mutant. If cells get occasional access to limited amount of glucose for short periods of time, the elevated glucose uptake rate selectively improves survival of the respiring Z. mobilis phenotype.
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Registered trials
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