Evidence map›Paper›PMID 27100730›Full record

ArticleBritish journal of cancer2016

Association between dietary inflammatory potential and breast cancer incidence and death: results from the Women's Health Initiative.

Fred K Tabung, Susan E Steck, Angela D Liese, Jiajia Zhang, Yunsheng Ma, Bette Caan, Rowan T Chlebowski, Jo L Freudenheim, Lifang Hou, Yasmin Mossavar-Rahmani and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 5 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 5 syntheses or guidelines pooled it, 104 citations in OpenAlex.

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  7. Dietary Inflammatory Index, Bone Mineral Density, and Risk of Fracture in Postmenopausal Women: Results From the Women's Health Initiative.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017
    Trial
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  9. Food-Based Dietary Inflammatory Index in Relation to Breast Cancer.International journal of preventive medicine · 2026
    Article
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 1 country.

Fred K TabungDepartments of Nutrition and Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Susan E SteckDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Angela D LieseDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Jiajia ZhangDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Yunsheng MaDivision of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
Bette CaanKaiser Permanente Division of Research, Oakland, CA, USA.
Rowan T ChlebowskiLos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LABioMed), Torrance, CA, USA.
Jo L FreudenheimDepartment of Epidemiology and Environmental Health, University at Buffalo, The State University of New York, Buffalo, NY, USA.
Lifang HouDepartment of Preventive Medicine and the Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Yasmin Mossavar-RahmaniDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Nitin ShivappaDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Mara Z VitolinsDepartment of Epidemiology & Prevention, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, University at Buffalo, The State University of New York, Buffalo, NY, USA.
Judith K OckeneDivision of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
James R HébertDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
University of South Carolina · USUniversity at Buffalo, State University of New York · USUniversity of Massachusetts Chan Medical School · USAlbert Einstein College of Medicine · USHarvard University · USKaiser Permanente · USRobert H. Lurie Comprehensive Cancer Center of Northwestern UniversityUCLA Medical Center · USWake Forest University · US

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
Expanding Mentoring Capacity in High-Risk PopulationsK05CA136975 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HEBERT, JAMES R · 2009 to 2013
$801k
Dietary Inflammatory Index and Risk of Cancer in WomenF31CA177255 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI TABUNG, FRED KINYUY · 2013 to 2013
$37k
NCI NIH HHS F31 CA177255NCI NIH HHS K05 CA136975NCI NIH HHS P30 CA060553NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

backgroundDiet modulates inflammation and inflammatory markers have been associated with cancer outcomes. In the Women's Health Initiative, we investigated associations between a dietary inflammatory index (DII) and invasive breast cancer incidence and death.

methodsThe DII was calculated from a baseline food frequency questionnaire in 122 788 postmenopausal women, enrolled from 1993 to 1998 with no prior cancer, and followed until 29 August 2014. With median follow-up of 16.02 years, there were 7495 breast cancer cases and 667 breast cancer deaths. We used Cox regression to estimate multivariable-adjusted hazards ratios (HRs) and 95% confidence intervals (95% CIs) by DII quintiles (Q) for incidence of overall breast cancer, breast cancer subtypes, and deaths from breast cancer. The lowest quintile (representing the most anti-inflammatory diet) was the reference.

resultsThe DII was not associated with incidence of overall breast cancer (HRQ5vsQ1, 0.99; 95% CI, 0.91-1.07; Ptrend=0.83 for overall breast cancer). In a full cohort analysis, a higher risk of death from breast cancer was associated with consumption of more pro-inflammatory diets at baseline, after controlling for multiple potential confounders (HRQ5vsQ1, 1.33; 95% CI, 1.01-1.76; Ptrend=0.03).

conclusionsFuture studies are needed to examine the inflammatory potential of post-diagnosis diet given the suggestion from the current study that dietary inflammatory potential before diagnosis is related to breast cancer death.

Indexed as

AgedBiomarkersBreast NeoplasmsC-Reactive ProteinDietFeeding BehaviorFemaleFollow-Up StudiesHumansIncidenceInflammationInterleukinsMiddle AgedPostmenopauseProportional Hazards ModelsProspective StudiesBiomarkersC-Reactive ProteinInterleukinsTumor Necrosis Factor-alpha

Identifiers

PMID27100730
PMCPMC4891517
OpenAlexW1552049950

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.