Trial reportChild psychiatry and human development2017
The Effects of Intranasal Oxytocin Administration on Sensitive Caregiving in Mothers with Postnatal Depression.
Trial report in Child psychiatry and human development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- The positive effect of mother-performed infant massage on infantile eczema and maternal mental state: A randomized controlled trial.Frontiers in public health · 2022Trial
- Effects of Intranasal Oxytocin Across Various Depressive Disorders.Psychiatry investigation · 2025Article
- How does oxytocin modulate human behavior?Molecular psychiatry · 2025Review
- Postpartum Depression Epidemiology, Risk Factors, Diagnosis, and Management: An Appraisal of the Current Knowledge and Future Perspectives.Journal of clinical medicine · 2025Review
- Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025Review
- From antidepressants and psychotherapy to oxytocin, vagus nerve stimulation, ketamine and psychedelics: how established and novel treatments can improve social functioning in major depression.Frontiers in psychiatry · 2024Review
- The Mood, Mother and Child Study: Protocol for a Prospective Longitudinal Study and Randomized Controlled Trial.JMIR research protocols · 2023Article
- Article
- A Scientometric Review of Infant Cry and Caregiver Responsiveness: Literature Trends and Research Gaps over 60 Years of Developmental Study.Children (Basel, Switzerland) · 2023Review
- Oxytocin and Women Postpartum Depression: A Systematic Review of Randomized Controlled Trials.Neuropsychiatric disease and treatment · 2023Review
- Physical and Psychological Childbirth Experiences and Early Infant Temperament.Frontiers in psychology · 2022Article
- An Integrated Mechanistic Model of Mindfulness-Oriented Recovery Enhancement for Opioid-Exposed Mother-Infant Dyads.Frontiers in psychology · 2021Review
- The oxytocinergic system in PTSD following traumatic childbirth: endogenous and exogenous oxytocin in the peripartum period.Archives of women's mental health · 2020Review
- Pregnancy, postpartum and parity: Resilience and vulnerability in brain health and disease.Frontiers in neuroendocrinology · 2020Review
- Oxytocin during breastfeeding and maternal mood symptoms.Psychoneuroendocrinology · 2020Article
- Intergenerational transmission of depression: clinical observations and molecular mechanisms.Molecular psychiatry · 2019Review
- The Role of Intranasal Oxytocin in Anxiety and Depressive Disorders: A Systematic Review of Randomized Controlled Trials.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2019Review
- The association between hormones and antipsychotic use: a focus on postpartum and menopausal women.Therapeutic advances in psychopharmacology · 2019Review
- Article
- Pathophysiological mechanisms implicated in postpartum depression.Frontiers in neuroendocrinology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postnatal depression (PND) is common and negatively affects the mother-infant relationship; oxytocin (OT) has been found to have positive effects on parenting, although psychiatric disorders may reduce these effects. Thus, we explored the role of OT in mothers diagnosed with PND. A within-subject, randomized controlled double-blind design was used to test the effects of nasal administration of OT or placebo on sensitive caregiving. The outcome measures were perceptual and caregiving responses to prerecorded cry sounds, as well as observed maternal sensitivity. We found that in the OT condition mothers with PND were more likely to rate an infant cry as more urgent and they were more likely to indicate they would chose a harsh caregiving strategy in response. There was no effect of OT on maternal sensitive interaction with their own baby. Further research is required prior to consideration of OT administration in depressed mothers of infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.