ArticlePloS one2016
The Effectiveness of Percutaneous Vertebroplasty Is Determined by the Patient-Specific Bone Condition and the Treatment Strategy.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Biomechanical study of robot-navigated targeted cross-puncture percutaneous vertebroplasty for Kümmell's disease: finite element analysis.Frontiers in rehabilitation sciences · 2026Article
- Multiphysics finite element analysis of vertebral stability in simulated osteolytic lumbar defects treated withFrontiers in bioengineering and biotechnology · 2026Article
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- Biomechanical comparison between unilateral and bilateral percutaneous vertebroplasty for osteoporotic vertebral compression fractures: A finite element analysis.Frontiers in bioengineering and biotechnology · 2022Article
- Patient-specific numerical investigation of the correction of cervical kyphotic deformity based on a retrospective clinical case.Frontiers in bioengineering and biotechnology · 2022Article
- Three generations of treatments for osteoporotic vertebral fractures: what is the evidence?Orthopedic reviews · 2022Article
- CT-based structural analyses of vertebral fractures with polymeric augmentation: A study of cadaveric three-level spine segments.Computers in biology and medicine · 2021Article
- Cement Leakage in Percutaneous Vertebroplasty for Multiple Osteoporotic Vertebral Compression Fractures: A Prospective Cohort Study.Orthopedic research and reviews · 2020Article
- Optimizing bone cement stiffness for vertebroplasty through biomechanical effects analysis based on patient-specific three-dimensional finite element modeling.Medical & biological engineering & computing · 2018Article
- Image-guided minimally invasive percutaneous treatment of spinal metastasis.Experimental and therapeutic medicine · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeVertebral fragility fractures are often treated by injecting bone cement into the collapsed vertebral bodies (vertebroplasty). The mechanisms by which vertebroplasty induces pain relief are not completely understood yet and recent debates cast doubt over the outcome of the procedure. The controversy is intensified by inconsistent results of randomized clinical trials and biomechanical studies that have investigated the effectiveness or the change in biomechanical response due to the reinforcement. The purpose of this study was to evaluate the effectiveness of vertebroplasty, by varying the relevant treatment parameters and (a) computationally predicting the improvement of the fracture risk depending on the chosen treatment strategy, and (b) identifying the determinants of a successful treatment.
methodsA Finite Element model with a patient-specific failure criterion and direct simulation of PMMA infiltration in four lumbar vertebrae was used to assess the condition of the bone under compressive load before and after the virtual treatment, simulating in a total of 12000 virtual treatments.
resultsThe results showed that vertebroplasty is capable of reducing the fracture risk by magnitudes, but can also have a detrimental effect. Effectiveness was strongly influenced by interactions between local bone quality, cement volume and injection location. However, only a moderate number of the investigated treatment strategies were able to achieve the necessary improvement for preventing a fracture.
conclusionsWe conclude that the effectiveness of vertebroplasty is sensitive to the patient's condition and the treatment strategy.
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