Evidence map›Paper›PMID 27100579›Full record

Observational studyJournal of the American Geriatrics Society2016

Identification of Risk Factors for Mortality and Poor-Quality-of-Life Survival in Frail Older Women Participating in the Women's Health Initiative Observational Study.

Oleg Zaslavsky, Nancy F Woods, Andrea Z LaCroix, Jane A Cauley, Karen C Johnson, Barbara B Cochrane, Shira Zelber Sagi

Open access · bronzeAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of the American Geriatrics Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Oleg ZaslavskySchool of Nursing, University of Washington, Seattle, Washington.
Nancy F WoodsSchool of Nursing, University of Washington, Seattle, Washington.
Andrea Z LaCroixDivision of Epidemiology, University on California at San Diego, San Diego, California.
Jane A CauleyDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
Karen C JohnsonDepartment of Preventive Medicine, University of Tennessee, Memphis, Tennessee.
Barbara B CochraneSchool of Nursing, University of Washington, Seattle, Washington.
Shira Zelber SagiFaculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel.
University of Washington · USUniversity of California, San Diego · USUniversity of Haifa · ILUniversity of Pittsburgh · USUniversity of Tennessee Health Science Center · US

Funding

Women's Health Initiative Memory Study (WHIMS)N01WH44221 · WH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2009 to 2010
$3.1M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042119 · WH · YESHIVA UNIVERSITY · PI WASSERTHEIL-SMOLLER, SYLVIA · 1994 to 2001
$2.2M
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032101 · WH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI GRIMM, RICHARD H · 1993 to 2000
$1.7M
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032111 · WH · EMORY UNIVERSITY · PI WATTS, NELSON · 1993 to 2001
$1.6M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042123 · WH · MEDSTAR RESEARCH INSTITUTE · PI HOWARD, BARBARA V · 1994 to 2000
$1.4M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042109 · WH · STANFORD UNIVERSITY · PI STEFANICK, MARCIA L · 1994 to 2000
$1.4M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042114 · WH · KAISER FOUNDATION RESEARCH INSTITUTE · PI RITENBAUGH, CHERYL K · 1994 to 2000
$1.4M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042108 · WH · GEORGE WASHINGTON UNIVERSITY · PI HSIA, JUDITH · 1994 to 2000
$1.4M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042124 · WH · RUSH UNIVERSITY MEDICAL CENTER · PI BLACK, HENRY R · 1994 to 2000
$1.4M
CLIN CTR CLIN TRIAL/OBSERVATIONAL STUDY OF WHIN01WH042131 · WH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI O'SULLIVAN, MARY J · 1994 to 2000
$1.3M
WOMENS HEALTH INITIATIVE-N01WH22110N01WH022110 · WH · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ROSS, PRENTICE · 1992 to 2006
$1.2M
VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVEN01WH032105 · WH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEWIS, CORA E · 1993 to 2000
$1.2M
WHI NIH HHS N01 WH022110WHI NIH HHS N01WH24152WHI NIH HHS N01WH32100WHI NIH HHS N01WH32101WHI NIH HHS N01WH32102WHI NIH HHS N01WH32105WHI NIH HHS N01WH32106WHI NIH HHS N01WH32108WHI NIH HHS N01WH32109WHI NIH HHS N01WH32111WHI NIH HHS N01WH32112WHI NIH HHS N01WH32113WHI NIH HHS N01WH32115WHI NIH HHS N01WH32118WHI NIH HHS N01WH32119WHI NIH HHS N01WH32122WHI NIH HHS N01WH42107WHI NIH HHS N01WH42108WHI NIH HHS N01WH42109WHI NIH HHS N01WH42110WHI NIH HHS N01WH42111WHI NIH HHS N01WH42112WHI NIH HHS N01WH42113WHI NIH HHS N01WH42114WHI NIH HHS N01WH42115WHI NIH HHS N01WH42116WHI NIH HHS N01WH42117WHI NIH HHS N01WH42118WHI NIH HHS N01WH42119WHI NIH HHS N01WH42120WHI NIH HHS N01WH42121WHI NIH HHS N01WH42122WHI NIH HHS N01WH42123WHI NIH HHS N01WH42124WHI NIH HHS N01WH42125WHI NIH HHS N01WH42126WHI NIH HHS N01WH42129WHI NIH HHS N01WH42130WHI NIH HHS N01WH42131WHI NIH HHS N01WH42132WHI NIH HHS N01WH44221
6 · The paper itself

Abstract

objectivesTo identify potentially modifiable factors associated with overall and poor-quality-of-life (QoL) survival in physically frail older women.

designProspective study with 7 years of follow-up to examine mortality and, in survivors with a QoL measurement within the next 3 years, to examine poor- versus good-QoL patterns of survival.

settingWomen's Health Initiative Observational Study (WHI OS).

participantsFrail older women (N = 11,070; average age 72.6, range 65-82). MEASUREMENTS: Frailty was defined using the modified Fried criteria. Study outcomes were overall survival and global QoL. Risk factors were measured at the first follow-up clinic visit for WHI OS participants between 1997 and 2001.

resultsOf 11,070 frail women, 1,487 (13%) died. After 2,677 survivors with poor or unknown QoL were excluded at study baseline, 3,153 (46%) reported good QoL, and 1,263 (18%) reported poor QoL at the end of study follow-up; QoL measures for 2,490 (38%) were unavailable. Older age, history of cardiovascular disease, diabetes mellitus, poor self-rated health, body mass index less than 25.0 kg/m(2) , waist circumference greater than 88 cm, systolic blood pressure greater than 140 mmHg, high number and severity of somatic symptoms, smoking, and low education were associated with greater likelihood of poor-QoL survival. Cumulative baseline risk scores demonstrated an approximately linear increase in probability of poor-QoL survival with an increase in risk factors. The probability of poor-QoL survival was 0.19 (95% confidence interval (CI) = 0.15-0.22) in those with zero to two risk factors and 0.40 (95% CI = 0.35-0.44) in those with six or more risk factors.

conclusionSeveral potentially important risk factors for aging well that can be monitored in clinical and research settings, some of which are modifiable, were identified in a large group of frail old women.

Indexed as

Frail ElderlyGeriatric AssessmentQuality of LifeAgedAged, 80 and overFemaleHumansMortalityProspective StudiesRisk FactorsUnited Statesaging wellfrailtymortalityQoLsymptoms

Identifiers

PMID27100579
PMCPMC4843841
OpenAlexW2339011999

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.