Evidence map›Paper›PMID 27100566›Full record

ArticleAdvanced healthcare materials2016

Self-Assembly Protein Nanogels for Safer Cancer Immunotherapy.

Alberto Purwada, Ye F Tian, Weishan Huang, Kathleen M Rohrbach, Simrita Deol, Avery August, Ankur Singh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Self-assembly of amino acids toward functional biomaterials.Beilstein journal of nanotechnology · 2021
    Review
  6. Review
  7. Article
  8. Advances in engineering local drug delivery systems for cancer immunotherapy.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020
    Review
  9. Review
  10. Review
  11. Emerging Nano-/Microapproaches for Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019
    Review
  12. Article
  13. Article
  14. Biomaterials for vaccine-based cancer immunotherapy.Journal of controlled release : official journal of the Controlled Release Society · 2018
    Review
  15. Review
  16. Review
  17. Alterations to the Gut Microbiome Impair Bone Strength and Tissue Material Properties.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alberto PurwadaMeinig School of Biomedical Engineering, College of Engineering, Cornell University, Ithaca, NY, 14853, USA.
Ye F TianSibley School of Mechanical and Aerospace Engineering, College of Engineering, Cornell University, Ithaca, NY, 14853, USA.
Weishan HuangDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA.
Kathleen M RohrbachDepartment of Material Science and Engineering, College of Engineering, Cornell University, Ithaca, NY, 14853, USA.
Simrita DeolDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA.
Avery AugustDepartment of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA.
Ankur SinghSibley School of Mechanical and Aerospace Engineering, College of Engineering, Cornell University, Ithaca, NY, 14853, USA.

Funding

Zeiss LSM710 Confocal Microscope for Shared Imaging FacilityS10RR025502 · NCRR · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2009 to 2009
$500k
(PQD5)Biomaterials-based Adaptive Tumor Microenvironments for In Vitro Drug ScreeR21CA185236 · NCI · CORNELL UNIVERSITY · PI CERCHIETTI, LEANDRO C, SINGH, ANKUR · 2014 to 2015
$395k
Howard Hughes Medical Institute 56006761NCI NIH HHS R21 CA185236NCRR NIH HHS S10 RR025502
6 · The paper itself

Abstract

Soluble antigen-based cancer vaccines have poor retention in tissues along with suboptimal antigen processing by dendritic cells. Multiple booster doses are often needed, leading to dose-limiting systemic toxicity. A versatile, immunomodulatory, self-assembly protein nanogel vaccine is reported that induces robust immune cell response at lower antigen doses than soluble antigens, an important step towards biomaterials-based safer immunotherapy approaches.

Indexed as

Antigens, NeoplasmCancer VaccinesImmunotherapyNeoplasm ProteinsNeoplasmsAnimalsHumansMiceNanoparticlesAntigens, NeoplasmCancer VaccinesNeoplasm ProteinsantigenimmunomodulationimmunotherapynanogelsT cell

Identifiers

PMID27100566
PMCPMC5532174

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.