Evidence map›Paper›PMID 27100476›Full record

ArticleJournal of medicinal chemistry2016

Near-Infrared Illumination of Native Tissues for Image-Guided Surgery.

Eric A Owens, Hoon Hyun, Tyler L Dost, Jeong Heon Lee, GwangLi Park, Dang Huan Pham, Min Ho Park, Hak Soo Choi, Maged Henary

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Tissue-seeking dyes for in vivo applications.Smart molecules : open access · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Near-Infrared Contrast Agents for Bone-Targeted Imaging.Tissue engineering and regenerative medicine · 2019
    Review
  18. Article
  19. Real-Time Fluorescence Imaging in Thoracic Surgery.The Korean journal of thoracic and cardiovascular surgery · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eric A OwensCenter for Diagnostics and Therapeutics, Center for Biotechnology and Drug Design, Department of Chemistry, Georgia State University , Petit Science Center, 100 Piedmont Ave SE, Atlanta, Georgia 30303, United States.
Hoon HyunGordon Center for Medical Imaging, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts 02114, United States.
Tyler L DostCenter for Diagnostics and Therapeutics, Center for Biotechnology and Drug Design, Department of Chemistry, Georgia State University , Petit Science Center, 100 Piedmont Ave SE, Atlanta, Georgia 30303, United States.
Jeong Heon LeeGordon Center for Medical Imaging, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts 02114, United States.
GwangLi ParkGordon Center for Medical Imaging, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts 02114, United States.
Dang Huan Pham
Min Ho Park
Hak Soo ChoiGordon Center for Medical Imaging, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts 02114, United States.
Maged HenaryCenter for Diagnostics and Therapeutics, Center for Biotechnology and Drug Design, Department of Chemistry, Georgia State University , Petit Science Center, 100 Piedmont Ave SE, Atlanta, Georgia 30303, United States.

Funding

Image-Guided Surgery of Endocrine Glands and Their Tumors using Near-Infrared FluR01EB011523 · NIBIB · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHOI, HAK SOO · 2010 to 2013
$2.0M
NIBIB NIH HHS R01 EB011523
6 · The paper itself

Abstract

Our initial efforts to prepare tissue-specific near-infrared (NIR) fluorescent compounds generated successful correlation between physicochemical properties and global uptake in major organs after systemic circulation and biodistribution. Herein, we focus on the effects on biodistribution based on modulating electronic influencing moieties from donating to withdrawing moieties at both the heterocyclic site and through meso-substitution of pentamethine cyanine fluorophores. These selected modifications harnessed innate biodistribution pathways through the structure-inherent targeting, resulting in effective imaging of the adrenal glands, pituitary gland, lymph nodes, pancreas, and thyroid and salivary glands. These native-tissue contrast agents will arm surgeons with a powerful and versatile arsenal for intraoperative NIR imaging in real time.

Indexed as

Surgery, Computer-AssistedAdrenal GlandsAnimalsCarbocyaninesFluorescent DyesLymph NodesMaleMiceMolecular ImagingNIH 3T3 CellsPancreasPituitary GlandSalivary GlandsThyroid GlandTissue DistributionCarbocyaninesFluorescent Dyes

Identifiers

PMID27100476
PMCPMC5733074

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.