ArticleAngewandte Chemie (International ed. in English)2016
Heterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclization Involved in their Biosynthesis.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Molecular basis for the biosynthesis of the siderophore coprogen in the cheese-ripening fungus Penicillium roqueforti.Biological research · 2025Article
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- Lienhwalides: Unique Tropolone-Maleidride Hybrids from Hypoxylon lienhwacheense.Chembiochem : a European journal of chemical biology · 2025Article
- Synthetic Biology in Natural Product Biosynthesis.Chemical reviews · 2025Review
- Sporothioethers: deactivated alkyl citrates from the fungusRSC advances · 2023Article
- Investigations into Simplified Analogues of the Herbicidal Natural Product (+)-Cornexistin.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Maleidride biosynthesis - construction of dimeric anhydrides - more than just heads or tails.Natural product reports · 2023Review
- Heterologous Expression of Secondary Metabolite Genes inJournal of fungi (Basel, Switzerland) · 2022Article
- Branching and converging pathways in fungal natural product biosynthesis.Fungal biology and biotechnology · 2022Review
- In silico analyses of maleidride biosynthetic gene clusters.Fungal biology and biotechnology · 2022Article
- EngineeringJournal of fungi (Basel, Switzerland) · 2021Article
- Secondary metabolite biosynthetic diversity in the fungal familyStudies in mycology · 2021Article
- Article
- Cleaning the Cellular Factory-Deletion of McrA inFrontiers in fungal biology · 2021Article
- Food-Poisoning Bacteria Employ a Citrate Synthase and a Type II NRPS To Synthesize Bolaamphiphilic Lipopeptide Antibiotics*.Angewandte Chemie (International ed. in English) · 2020Article
- The sporothriolides. A new biosynthetic family of fungal secondary metabolites.Chemical science · 2020Article
- Uncovering biosynthetic relationships between antifungal nonadrides and octadrides.Chemical science · 2020Article
- Total Synthesis of (+)-Cornexistin.Angewandte Chemie (International ed. in English) · 2020Article
- Unearthing fungal chemodiversity and prospects for drug discovery.Current opinion in microbiology · 2019Review
- Structure revision of cryptosporioptides and determination of the genetic basis for dimeric xanthone biosynthesis in fungi.Chemical science · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Fungal maleidrides are an important family of bioactive secondary metabolites that consist of 7, 8, or 9-membered carbocycles with one or two fused maleic anhydride moieties. The biosynthesis of byssochlamic acid (a nonadride) and agnestadride A (a heptadride) was investigated through gene disruption and heterologous expression experiments. The results reveal that the precursors for cyclization are formed by an iterative highly reducing fungal polyketide synthase supported by a hydrolase, together with two citrate-processing enzymes. The enigmatic ring formation is catalyzed by two proteins with homology to ketosteroid isomerases, and assisted by two proteins with homology to phosphatidylethanolamine-binding proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.