Evidence map›Paper›PMID 27099858›Full record

ArticleCase reports in nephrology and dialysis

Treatment of Focal Segmental Glomerulosclerosis Recurrence in the Renal Allograft: A Report of Two Cases.

Minh-Ha Tran, Cynthia Chan, Whitney Pasch, Philip Carpenter, Hirohito Ichii, Clarence Foster

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in nephrology and dialysis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Recurrent andFrontiers in immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Minh-Ha TranDepartment of Pathology and Laboratory Medicine, UC Irvine Health School of Medicine, USA.
Cynthia ChanDepartment of Pharmacy, UC Irvine Health Medical Center, Inpatient Pharmacy, Orange, Calif., USA.
Whitney PaschUCLA Olive View, University of Southern California, Los Angeles, Calif., USA.
Philip CarpenterDepartment of Pathology and Laboratory Medicine, UC Irvine Health School of Medicine, USA; Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, Calif., USA.
Hirohito IchiiDivision of Transplantation, Department of Surgery, UC Irvine Health School of Medicine, Orange, Calif., USA.
Clarence FosterDivision of Transplantation, Department of Surgery, UC Irvine Health School of Medicine, Orange, Calif., USA.
UC Irvine Health · USOlive View-UCLA Medical Center · USOrange (France) · FRUniversity of Southern California · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Institutional Career Development CoreKL2TR001416 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, DEMETRIOU, MICHAEL · 2015 to 2023
$5.6M
NCATS NIH HHS KL2 TR001416NCATS NIH HHS UL1 TR001414
6 · The paper itself

Abstract

Focal segmental glomerulosclerosis (FSGS) causes glomerular lesions that can progress to end-stage renal disease. It is suspected to be caused by a circulating factor that is amenable to plasmapheresis removal and exhibits a risk for recurrence in the renal allograft. We present two patients with FSGS recurrence in their allograft kidneys diagnosed by biopsy after significant proteinuria developed in the posttransplant setting. Treatment with therapeutic plasma exchange induced long-term remission in both patients. Spot urine protein:creatinine ratios were monitored and treatment was continued until a target of <0.5 was achieved. In patient number two, a second peak in proteinuria and azotemia was ultimately attributable to ureteral stenosis and these values normalized following repair. In conclusion, therapeutic plasma exchange is an effective treatment for FSGS recurring following renal transplant.

Indexed as

Complications of kidney transplantationFocal segmental glomerulosclerosisIntravenous immune globulinKidney transplantationRenal allograftRituximabTherapeutic plasma exchange

Identifiers

PMID27099858
PMCPMC4836136
OpenAlexW2317985594

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.