ArticleBrain and behavior2016
Microstructural white-matter abnormalities and their relationship with cognitive dysfunction in obsessive-compulsive disorder.
Article in Brain and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- White matter abnormalities in paediatric obsessive-compulsive disorder: a systematic review of diffusion tensor imaging studies.Brain imaging and behavior · 2023Pooled it
- Microstructural white matter abnormalities in pediatric and adult obsessive-compulsive disorder: A systematic review and meta-analysis.Brain and behavior · 2021Pooled it
- Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra-high risk for psychosis.Human brain mapping · 2019Trial
- Trial
- Neuroimaging and Machine Learning in OCD: Advances in Diagnostic and Therapeutic Insights.Brain sciences · 2025Review
- Pre-CBT resting-state connectivity and white matter integrity in OCD remission: A multimodal MRI study.Neuroimage. Reports · 2025Article
- Abnormal spontaneous regional white-matter brain activity in patients with obsessive-compulsive disorder.Frontiers in psychology · 2025Article
- Age of onset of obsessive-compulsive disorder differentially affects white matter microstructure.Molecular psychiatry · 2024Article
- Toward identifying reproducible brain signatures of obsessive-compulsive profiles: rationale and methods for a new global initiative.BMC psychiatry · 2020Article
- Neuroimaging findings in obsessive-compulsive disorder: A narrative review to elucidate neurobiological underpinnings.Indian journal of psychiatry · 2019Review
- Structural Correlates of Personality Dimensions in Healthy Aging and MCI.Frontiers in psychology · 2018Article
- The detection of white matter alterations in obsessive-compulsive disorder revealed by TRActs Constrained by UnderLying Anatomy (TRACULA).Neuropsychiatric disease and treatment · 2018Article
- Abnormal white matter structural connectivity in adults with obsessive-compulsive disorder.Translational psychiatry · 2017Article
- Microstructural white-matter abnormalities and their relationship with cognitive dysfunction in obsessive-compulsive disorder.Brain and behavior · 2016Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundIn recent years, diffusion tensor imaging (DTI) studies have detected subtle microstructural abnormalities of white matter (WM) in obsessive-compulsive disorder (OCD). However, findings have been inconsistent, and it is unclear whether WM abnormalities are related to cognitive processes. The aim of this study was to explore the relationship of WM alterations with cognitive variables in OCD in order to investigate the structural correlates of behaviorally relevant features of the disorder.
methodsWe compared DTI-derived fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) measures between OCD patients (n = 16) and healthy controls (n = 18) using a whole-brain tract-based spatial statistics (TBSS) approach. We also explored the correlations of WM alterations with clinical and cognitive variables.
resultsPatients with OCD demonstrated increases in MD in the bilateral posterior corona radiata; left anterior corona radiata; bilateral superior longitudinal fasciculus; genu, body, and splenium of the corpus callosum; and left posterior limb of the internal capsule. An increase in RD values was also found in some of the same tracts (right posterior corona radiata, right superior longitudinal fasciculus, left anterior corona radiata, and corpus callosum). Furthermore, increased MD value in the internal capsule was correlated with the percentage of errors made during a target detection task, which was greater in the OCD group overall.
conclusionsThese findings indicate that OCD patients show greater diffusivity in several white-matter regions. The correlation between cognitive performance and diffusivity in the internal capsule suggests that microstructural WM alternations may have functional consequences for the disorder.
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