Evidence map›Paper›PMID 27099802›Full record

ArticleBrain and behavior2016

Disrupted functional brain network organization in patients with obstructive sleep apnea.

Bumhee Park, Jose A Palomares, Mary A Woo, Daniel W Kang, Paul M Macey, Frisca L Yan-Go, Ronald M Harper, Rajesh Kumar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.

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  17. Breathing rate variability in obstructive sleep apnea during wakefulness.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Bumhee ParkDepartment of Anesthesiology University of California at Los Angeles Los Angeles CA 90095.
Jose A PalomaresDepartment of Anesthesiology University of California at Los Angeles Los Angeles CA 90095.
Mary A WooUCLA School of Nursing University of California at Los Angeles Los Angeles CA 90095.
Daniel W KangDepartment of Medicine University of California at Los Angeles Los Angeles California 90095.
Paul M MaceyUCLA School of Nursing University of California at Los Angeles Los Angeles CA 90095; The Brain Research Institute University of California at Los Angeles Los Angeles California 90095.
Frisca L Yan-GoDepartment of Neurology University of California at Los Angeles Los Angeles California 90095.
Ronald M HarperThe Brain Research Institute University of California at Los Angeles Los Angeles California 90095; Department of Neurobiology University of California at Los Angeles Los Angeles California 90095.
Rajesh KumarDepartment of Anesthesiology University of California at Los Angeles Los Angeles CA 90095; The Brain Research Institute University of California at Los Angeles Los Angeles California 90095; Department of Radiological Sciences University of California at Los Angeles Los Angeles California 90095; Department of Bioengineering University of California at Los Angeles Los Angeles California 90095.
University of California, Los Angeles · US

Funding

Blood-Brain Barrier Deficit and Brain Injury in Obstructive Sleep ApneaR01NR015038 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH · 2015 to 2018
$2.0M
Brain Axonal Injury in Obstructive Sleep ApneaR01HL113251 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH · 2012 to 2015
$1.4M
NHLBI NIH HHS R01 HL-113251NHLBI NIH HHS R01 HL113251NINR NIH HHS R01 NR-015038NINR NIH HHS R01 NR015038
6 · The paper itself

Abstract

introductionObstructive sleep apnea (OSA) subjects show impaired autonomic, affective, executive, sensorimotor, and cognitive functions. Brain injury in OSA subjects appears in multiple sites regulating these functions, but the integrity of functional networks within the regulatory sites remains unclear. Our aim was to examine the functional interactions and the complex network organization of these interactions across the whole brain in OSA, using regional functional connectivity (FC) and brain network topological properties.

methodsWe collected resting-state functional magnetic resonance imaging (MRI) data, using a 3.0-Tesla MRI scanner, from 69 newly diagnosed, treatment-naïve, moderate-to-severe OSA (age, 48.3 ± 9.2 years; body mass index, 31 ± 6.2 kg/m(2); apnea-hypopnea index (AHI), 35.6 ± 23.3 events/h) and 82 control subjects (47.6 ± 9.1 years; body mass index, 25.1 ± 3.5 kg/m(2)). Data were analyzed to examine FC in OSA over controls as interregional correlations and brain network topological properties.

resultsObstructive sleep apnea subjects showed significantly altered FC in the cerebellar, frontal, parietal, temporal, occipital, limbic, and basal ganglia regions (FDR, P < 0.05). Entire functional brain networks in OSA subjects showed significantly less efficient integration, and their regional topological properties of functional integration and specialization characteristics also showed declined trends in areas showing altered FC, an outcome which would interfere with brain network organization (P < 0.05; 10,000 permutations). Brain sites with abnormal topological properties in OSA showed significant relationships with AHI scores.

conclusionsOur findings suggest that the dysfunction extends to resting conditions, and the altered FC and impaired network organization may underlie the impaired responses in autonomic, cognitive, and sensorimotor functions. The outcomes likely result from the prominent structural changes in both axons and nuclear structures, which occur in the condition.

Indexed as

AdultAgedAutonomic Nervous SystemBrainBrain MappingCerebellumCognitionConnectomeCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRestSensorimotor CortexFunctional magnetic resonance imagingfunctional networkgraph theoryspontaneous activity

Identifiers

PMID27099802
PMCPMC4831421
OpenAlexW2333441880

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.