ArticleBrain and behavior2016
Evidence for cerebral edema, cerebral perfusion, and intracranial pressure elevations in acute mountain sickness.
Article in Brain and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- A Single Night in Hypoxia Either with or without Ketone Ester Ingestion Reduces Sleep Quality without Impacting Next-Day Exercise Performance.Medicine and science in sports and exercise · 2025Trial
- Intermittent hypoxia preconditioning can attenuate acute hypoxic injury after a sustained normobaric hypoxic exposure: A randomized clinical trial.CNS neuroscience & therapeutics · 2024Trial
- The effects of normobaric and hypobaric hypoxia on cognitive performance and physiological responses: A crossover study.PloS one · 2022Trial
- Barometric pressure variability and shunt-related hospital encounters in the pediatric population: a retrospective analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- A comparison of normobaric and hypobaric hypoxia effects on cerebrovascular response pre and post maximal exercise.Experimental physiology · 2026Article
- Repurposing space medical technology for perioperative and intensive care: a clinical proof-of-concept.British journal of anaesthesia · 2025Article
- Exosomes from high-altitude cerebral edema patients induce cognitive dysfunction by altering oxidative stress responses in mice.Translational psychiatry · 2025Article
- Hyperbaric oxygen preconditioning for prevention of acute high-altitude diseases: Fact or fiction?Frontiers in physiology · 2023Article
- Mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortex.Biological research · 2021Article
- Optic Nerve Ultrasound Evaluation in Animals and Normal Subjects.Frontiers in medicine · 2021Review
- Cardio-respiratory, oxidative stress and acute mountain sickness responses to normobaric and hypobaric hypoxia in prematurely born adults.European journal of applied physiology · 2020Article
- IL-10 Dysregulation in Acute Mountain Sickness Revealed by Transcriptome Analysis.Frontiers in immunology · 2017Article
- Article
- The incidence of increased ICP in ICU patients with non-traumatic coma as diagnosed by ONSD and CT: a prospective cohort study.BMC anesthesiology · 2016Article
- Evidence for cerebral edema, cerebral perfusion, and intracranial pressure elevations in acute mountain sickness.Brain and behavior · 2016Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe hypothesized that cerebral alterations in edema, perfusion, and/or intracranial pressure (ICP) are related to the development of acute mountain sickness (AMS).
methodsTo vary AMS, we manipulated ambient oxygen, barometric pressure, and exercise duration. Thirty-six subjects were tested before, during and after 8 h exposures in (1) normobaric normoxia (NN; 300 m elevation equivalent); (2) normobaric hypoxia (NH; 4400 m equivalent); and (3) hypobaric hypoxia (HH; 4400 m equivalent). After a passive 15 min ascent, each subject participated in either 10 or 60 min of cycling exercise at 50% of heart rate reserve. We measured tissue absorption and scattering via radio-frequency near-infrared spectroscopy (NIRS), optic nerve sheath diameter (ONSD) via ultrasound, and AMS symptoms before, during, and after environmental exposures.
resultsWe observed significant increases in NIRS tissue scattering of 0.35 ± 0.11 cm(-1) (P = 0.001) in subjects with AMS (i.e., AMS+), consistent with mildly increased cerebral edema. We also noted a small, but significant increase in total hemoglobin concentrations with AMS+, 3.2 ± 0.8 μmolL(-1) (P < 0.0005), consistent with increased cerebral perfusion. No effect of exercise duration was found, nor did we detect differences between NH and HH. ONSD assays documented a small but significant increase in ONSD (0.11 ± 0.02 mm; P < 0.0005) with AMS+, suggesting mildly elevated ICP, as well as further increased ONSD with longer exercise duration (P = 0.005).
conclusionIn AMS+, we found evidence of cerebral edema, elevated cerebral perfusion, and elevated ICP. The observed changes were small but consistent with the reversible nature of AMS.
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