Evidence map›Paper›PMID 27099765›Full record

ArticleLupus science & medicine2016

Cardiovascular events prior to or early after diagnosis of systemic lupus erythematosus in the systemic lupus international collaborating clinics cohort.

M B Urowitz, D D Gladman, N M Anderson, J Su, J Romero-Diaz, S C Bae, P R Fortin, J Sanchez-Guerrero, A Clarke, S Bernatsky and 31 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lupus science & medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
9.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Pooled it
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  16. Cardiovascular Implications of Immune Disorders in Women.Circulation research · 2022 · on this map
    Review
  17. Review
  18. Cardiovascular disease in systemic lupus erythematosus.Rheumatology and immunology research · 2021
    Review
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  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

41 authors at 20 institutions in 11 countries.

M B UrowitzCentre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto , Toronto Ontario , Canada.
D D GladmanCentre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto , Toronto Ontario , Canada.
N M AndersonCentre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto , Toronto Ontario , Canada.
J SuCentre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto , Toronto Ontario , Canada.
J Romero-DiazInstituto Nacional de Ciencias Medicas y Nutrición , Mexico City , Mexico.
S C BaeDepartment of Rheumatology , Hanyang University Hospital for Rheumatic Diseases , Seoul , Korea.
P R FortinDivision of Rheumatology , Centre Hospitalier Universitaire de Québec et Université Laval , Quebec City , Canada.
J Sanchez-GuerreroCentre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto , Toronto Ontario , Canada.
A ClarkeDivision of Rheumatology , Cumming School of Medicine University of Calgary , Calgary, Alberta , Canada.
S BernatskyDivisions of Clinical Immunology/Allergy and Clinical Epidemiology , Montreal General Hospital, McGill University Health Centre , Montreal, Quebec , Canada.
C GordonRheumatology Research Group , School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham , Birmingham , UK.
J G HanlyDivision of Rheumatology, Department of Medicine and Department of Pathology , Queen Elizabeth II Health Sciences Centre and Dalhousie University , Halifax, Nova Scotia , Canada.
D J WallaceCedars-Sinai/David Geffen School of Medicine at UCLA , Los Angeles, California , USA.
D IsenbergCentre for Rheumatology Research, University College , London , UK.
A RahmanCentre for Rheumatology Research, University College , London , UK.
J MerrillDepartment of Clinical Pharmacology , Oklahoma Medical Research Foundation , Oklahoma City, Oklahoma , USA.
E GinzlerDepartment of Medicine , SUNY Downstate Medical Center , Brooklyn, New York , USA.
G S AlarcónDepartment of Medicine, Division of Clinical Immunology and Rheumatology , University of Alabama at Birmingham , Birmingham, Alabama , USA.
B F FesslerDepartment of Medicine, Division of Clinical Immunology and Rheumatology , University of Alabama at Birmingham , Birmingham, Alabama , USA.
M PetriDepartment of Rheumatology , Johns Hopkins University School of Medicine , Baltimore, Maryland , USA.
I N BruceArthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, London, UK.
M KhamashtaLupus Research Unit , The Rayne Institute, St Thomas' Hospital, King's College London School of Medicine , London , UK.
C AranowFeinstein Institute for Medical Research , Manhasset, New York , USA.
M DooleyDivision of Rheumatology and Immunology, Department of Medicine , University of North Carolina , Chapel Hill, North Carolina , USA.
S ManziDepartment of Medicine , West Penn Allegheny , Pittsburgh, Pennsylvania , USA.
R Ramsey-GoldmanNorthwestern University and Feinberg School of Medicine , Chicago, Illinois , USA.
G SturfeltDepartment of Rheumatology , University Hospital Lund , Lund , Sweden.
O NivedDepartment of Rheumatology , University Hospital Lund , Lund , Sweden.
K SteinssonDepartment of Rheumatology , Center for Rheumatology Research Fossvogur Landspitali University Hospital , Reyjkavik , Iceland.
A ZomaLanarkshire Centre for Rheumatology, Hairmyres Hospital , East Kilbride, Scotland , UK.
G Ruiz-IrastorzaAutoimmune Disease Unit, Department of Internal Medicine , Hospital Universitario Cruces., University of the Basque Country , Barakaldo , Spain.
S LimDivision of Rheumatology, Emory University School of Medicine , Atlanta, Georgia , USA.
K C KalunianUCSD School of Medicine , La Jolla, California , USA.
M ỈnançDivision of Rheumatology, Department of Internal Medicine, Istanbul Medical Faculty , Istanbul University , Istanbul , Turkey.
R van VollenhovenUnit for Clinical Therapy Research (ClinTRID), The Karolinska Institute , Stockholm , Sweden.
M Ramos-CasalsJosep Font Autoimmune Diseases Laboratory, IDIBAPS, Department of Autoimmune Diseases , Hospital Clínic , Barcelona , Spain.
D L KamenDivision of Rheumatology, Medical University of South Carolina , Charleston, South Carolina , USA.
S JacobsenDepartment of Rheumatology Rigshospitalet , Copenhagen University Hospital , Copenhagen , Denmark.
C PeschkenDepartment of Medicine and Community Health Sciences, University of Manitoba , Winnipeg, Manitoba , Canada.
A AskanaseDivision of Rheumatology, Columbia University Medical Center , New York , USA.
T StollDepartment of Rheumatology , Kantousspital , Schaffhausen , Switzerland.
Toronto Western Hospital · CABritish Society for Rheumatology · GBLund University · SEUniversity of Alabama at Birmingham · USCedars-Sinai Medical Center · USColumbia University Irving Medical Center · USCopenhagen University Hospital · DKDalhousie University · CAEmory University · USFeinstein Institute for Medical Research · USHairmyres Hospital · GBHanyang University Seoul Hospital · KRHospital Clínic de Barcelona · ESInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXIstanbul University · TRJohns Hopkins Medicine · USKarolinska Institutet · SEManchester Academic Health Science Centre · GBMcGill University Health Centre · CAMedical University of South Carolina · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe the frequency of myocardial infarction (MI) prior to the diagnosis of systemic lupus erythematosus (SLE) and within the first 2 years of follow-up.

methodsThe systemic lupus international collaborating clinics (SLICC) atherosclerosis inception cohort enters patients within 15 months of SLE diagnosis. MIs were reported and attributed on a specialised vascular event form. MIs were confirmed by one or more of the following: abnormal ECG, typical or atypical symptoms with ECG abnormalities and elevated enzymes (≥2 times upper limit of normal), or abnormal stress test, echocardiogram, nuclear scan or angiogram. Descriptive statistics were used.

results31 of 1848 patients who entered the cohort had an MI. Of those, 23 patients had an MI prior to SLE diagnosis or within the first 2 years of disease. Of the 23 patients studied, 60.9% were female, 78.3% were Caucasian, 8.7% black, 8.7% Hispanic and 4.3% other. The mean age at SLE diagnosis was 52.5±15.0 years. Of the 23 MIs that occurred, 16 MIs occurred at a mean of 6.1±7.0 years prior to diagnosis and 7 occurred within the first 2 years of follow-up. Risk factors associated with early MI in univariate analysis are male sex, Caucasian, older age at diagnosis, hypertension, hypercholesterolaemia, family history of MI and smoking. In multivariate analysis only age (OR=1.06 95% CI 1.03 to 1.09), hypertension (OR=5.01, 95% CI 1.38 to 18.23), hypercholesterolaemia (OR=4.43, 95% CI 1.51 to 12.99) and smoking (OR=7.50, 95% CI 2.38 to 23.57) remained significant risk factors.

conclusionsIn some patients with lupus, MI may develop even before the diagnosis of SLE or shortly thereafter, suggesting that there may be a link between autoimmune inflammation and atherosclerosis.

Indexed as

Cardiovascular DiseaseInflammationSystemic Lupus Erythematosus

Identifiers

PMID27099765
PMCPMC4836282
OpenAlexW2338949780

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.