Evidence map›Paper›PMID 27099762›Full record

ArticleOpen heart

Long-term risk of atrial fibrillation after the death of a partner.

Simon Graff, Morten Fenger-Grøn, Bo Christensen, Henrik Søndergaard Pedersen, Jakob Christensen, Jiong Li, Mogens Vestergaard

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Article in Open heart. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  8. The Association of Perceived Stress and Atrial Fibrillation.Research in heart yield and translational medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Simon GraffDepartment of Public Health , Research Unit for General Practice, Aarhus University , Aarhus C , Denmark.
Morten Fenger-GrønDepartment of Public Health , Research Unit for General Practice, Aarhus University , Aarhus C , Denmark.
Bo ChristensenSection for General Practice, Department of Public Health , Aarhus University , Aarhus C , Denmark.
Henrik Søndergaard PedersenDepartment of Public Health , Research Unit for General Practice, Aarhus University , Aarhus C , Denmark.
Jakob ChristensenDepartment of Neurology , Aarhus University Hospital , Aarhus C , Denmark.
Jiong LiSection for Epidemiology, Department of Public Health , Aarhus University , Aarhus C , Denmark.
Mogens VestergaardDepartment of Public Health, Research Unit for General Practice, Aarhus University, Aarhus C, Denmark; Section for General Practice, Department of Public Health, Aarhus University, Aarhus C, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSevere psychological stress is generally associated with an increased risk of acute cardiovascular diseases, such as myocardial infarction, but it remains unknown whether it also applies to atrial fibrillation. We conducted a population-based case-control study using nationwide Danish health registers to examine the risk of atrial fibrillation after the death of a partner.

methodsFrom 1995 through 2014, we identified 88 612 cases with a hospital diagnosis of atrial fibrillation and 886 120 age-matched and sex-matched controls based on risk-set sampling. The conditional logistic regression model was used to calculate adjusted ORs of atrial fibrillation with 95% CIs.

resultsPartner bereavement was experienced by 17 478 cases and 168 940 controls and was associated with a transiently higher risk of atrial fibrillation; the risk was highest 8-14 days after the loss (1.90; 95% CI 1.34 to 2.69), after which it gradually declined. One year after the loss, the risk was almost the same as in the non-bereaved population. Overall, the OR of atrial fibrillation within 30 days after bereavement was 1.41 (95% CI 1.17 to 1.70), but it tended to be higher in persons below the age of 60 years (2.34; 95% CI 1.02 to 5.40) and in persons whose partner had a low predicted mortality 1 month before the death, that is, ≤5 points on the age-adjusted Charlson Comorbidity Index (1.57; 95% CI 1.13 to 2.17).

conclusionsThe severely stressful life event of losing a partner was followed by a transiently increased risk of atrial fibrillation lasting for 1 year, especially for the least predicted losses.

Identifiers

PMID27099762
PMCPMC4823543

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.