Evidence map›Paper›PMID 27099754›Full record

ArticleJournal of materials chemistry. B2015

Nanocoating for biomolecule delivery using layer-by-layer self-assembly.

M Keeney, X Y Jiang, M Yamane, M Lee, S Goodman, F Yang

Abstract read
In one paragraph

Article in Journal of materials chemistry. B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Chemical Sensor Nanotechnology in Pharmaceutical Drug Research.Nanomaterials (Basel, Switzerland) · 2022
    Review
  9. 2D layered nanomaterials for therapeutics delivery.Current opinion in biomedical engineering · 2021
    Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Organic Thin-Film Transistors as Gas Sensors: A Review.Materials (Basel, Switzerland) · 2020
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

M KeeneyDepartment of Orthopaedic Surgery, 300 Pasteur Dr., Edwards R105, Stanford, CA 94305, USA.
X Y JiangDepartment of Orthopaedic Surgery, 300 Pasteur Dr., Edwards R105, Stanford, CA 94305, USA.
M YamaneProgram of Human Biology, Stanford University, Stanford, CA 94305, USA.
M LeeDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA.
S GoodmanDepartment of Orthopaedic Surgery, 300 Pasteur Dr., Edwards R105, Stanford, CA 94305, USA.
F YangDepartment of Orthopaedic Surgery, 300 Pasteur Dr., Edwards R105, Stanford, CA 94305, USA; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

Funding

Microribbon scaffold-mediated Immunomodulation for Cranial Bone RepairR01DE024772 · NIDCR · STANFORD UNIVERSITY · PI YANG, FAN · 2015 to 2025
$4.6M
Wear Particle Disease and NF-kappa B SignalingR01AR063717 · NIAMS · STANFORD UNIVERSITY · PI GOODMAN, STUART B · 2012 to 2021
$3.5M
Chemokine Directed Cell Trafficking during Continuous Infusion of Wear ParticlesR01AR055650 · NIAMS · STANFORD UNIVERSITY · PI GOODMAN, STUART B · 2007 to 2016
$3.3M
NIAMS NIH HHS R01 AR055650NIAMS NIH HHS R01 AR063717NIDCR NIH HHS R01 DE024772
6 · The paper itself

Abstract

Since its introduction in the early 1990s, layer-by-layer (LbL) self-assembly of films has been widely used in the fields of nanoelectronics, optics, sensors, surface coatings, and controlled drug delivery. The growth of this industry is propelled by the ease of film manufacture, low cost, mild assembly conditions, precise control of coating thickness, and versatility of coating materials. Despite the wealth of research on LbL for biomolecule delivery, clinical translation has been limited and slow. This review provides an overview of methods and mechanisms of loading biomolecules within LbL films and achieving controlled release. In particular, this review highlights recent advances in the development of LbL coatings for the delivery of different types of biomolecules including proteins, polypeptides, DNA, particles and viruses. To address the need for co-delivery of multiple types of biomolecules at different timing, we also review recent advances in incorporating compartmentalization into LbL assembly. Existing obstacles to clinical translation of LbL technologies and enabling technologies for future directions are also discussed.

Identifiers

PMID27099754
PMCPMC4835036

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.