ArticleJournal of diabetes research & clinical metabolism
Migration and DNA methylation: a comparison of methylation patterns in type 2 diabetes susceptibility genes between indians and europeans.
Article in Journal of diabetes research & clinical metabolism. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- The impact of site-specific DNA methylation inHeliyon · 2024Article
- Type 2 diabetes is more closely associated with risk of colorectal cancer based on elevated DNA methylation levels of ADCY5.Oncology letters · 2022Article
- New insights from monogenic diabetes for "common" type 2 diabetes.Frontiers in genetics · 2015Review
- Fetal programming of adipose tissue function: an evolutionary perspective.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Review
- Differences in smoking associated DNA methylation patterns in South Asians and Europeans.Clinical epigenetics · 2014Article
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Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundType 2 diabetes is a global problem that is increasingly prevalent in low and middle income countries including India, and is partly attributed to increased urbanisation. Genotype clearly plays a role in type 2 diabetes susceptibility. However, the role of DNA methylation and its interaction with genotype and metabolic measures is poorly understood. This study aimed to establish whether methylation patterns of type 2 diabetes genes differ between distinct Indian and European populations and/or change following rural to urban migration in India.
methodsQuantitative DNA methylation analysis in Indians and Europeans using Sequenom
resultsConsistent differences in DNA methylation patterns were observed between Indian and European populations in ADCY5, FTO and KCNJ11. Associations were demonstrated between FTO rs9939609 and BMI and between ADCY5rs17295401 and HDL levels in Europeans. However, these observations were not linked to local variation in DNA methylation levels. No differences in methylation patterns were observed in urban-dwelling migrants compared to their non-migrant rural-dwelling siblings in India.
conclusionsAnalysis of DNA methylation at three type 2 diabetes susceptibility loci highlighted geographical and ethnic differences in methylation patterns. These differences may be attributed to genetic and/or region-specific environmental factors.
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