Evidence map›Paper›PMID 27099673›Full record

ArticleGastroenterology and hepatology from bed to bench2016

Cancer stem cells CD133 and CD24 in colorectal cancers in Northern Iran.

Anahita Nosrati, Farshad Naghshvar, Iradj Maleki, Fatemeh Salehi

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Gastroenterology and hepatology from bed to bench, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Anahita NosratiDepartment of Pathology, Gastrointestinal Cancer Research Center, Imam Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
Farshad NaghshvarDepartment of Pathology, Imam Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
Iradj MalekiGut and Liver Research Center, Department of Gastroenterology, Imam Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
Fatemeh SalehiDepartment of Pathology, Imam Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
Mazandaran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimWe aimed to study the expression of CD24 and CD133 in colorectal cancer and normal adjacent tissues to assess a relationship between these markers and clinic-pathological characteristics and patient's survival.

backgroundCancer stem cells are a group of tumor cells that have regeneration and multi-order differentiation capabilities. PATIENTS AND

methodsExpression of CD24 and CD133 was studied in a paraffin block of colorectal cancer and normal tissues near tumors with the immuneohistochemical method in patients who were referred to Imam Khomeini Hospital in Sari.

resultsA total of 50 samples (25 males and 25 females) with a mean age of 67.57±13.9 years old with range 28-93 years, included 3 mucinous carcinoma and 47 adenocarcinoma. Expression of CD133 marker was negative in 29 cases and positive in 21 cases. Expression of CD24 in tissue near tumor cells was found in 30% of available samples. The relationship between expressing CD24 with treatment (surgery and chemotherapy) was significant and its relationship with patient's survival was insignificant statistically. However, there was a clear difference as mean survival age of patients based on CD24 expression was 26.64±18.15 for negative cases and 41.75±28.76 months for positive cases. CD24 and CD133 expressions and their co-expression with other clinic-pathological factors were not significant.

conclusionDuring this study, the relationship between CD24 and treatment type was significant. To confirm this result, various studies with high sample numbers and other stem cell markers are recommended.

Indexed as

Cancer stem cellsCD133CD24Clinicopathologic characteristicsColorectal cancer

Identifiers

PMID27099673
PMCPMC4833852
OpenAlexW2309195005

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.