Evidence map›Paper›PMID 27099595›Full record

ArticleGastroenterology & hepatology2015

EUS-Guided Needle-Based Confocal Laser Endomicroscopy: A Novel Technique With Emerging Applications.

Manoop S Bhutani, Pramoda Koduru, Virendra Joshi, John G Karstensen, Adrian Saftoiu, Peter Vilmann, Marc Giovannini

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Gastroenterology & hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

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  7. The role of confocal laser endomicroscopy in pulmonary medicine.European respiratory review : an official journal of the European Respiratory Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Manoop S BhutaniDr Bhutani is a professor and Dr Koduru is a research intern in the Department of Gastroenterology, Hepatology, and Nutrition at the University of Texas MD Anderson Cancer Center in Houston, Texas. Dr Joshi is an associate professor in the Department of Gastroenterology at the Ochsner Clinic Foundation in New Orleans, Louisiana. Dr Karstensen is a research fellow, Dr Saftoiu is a visiting professor, and Dr Vilmann is a professor at the University of Copenhagen Herlev Hospital in Herlev, Denmark. Dr Saftoiu is also a professor at the Research Center of Gastroenterology and Hepatology at the University of Medicine and Pharmacy of Craiova in Craiova, Romania. Dr Giovannini is a professor at the Institut Paoli-Calmettes in Marseille, France.
Pramoda KoduruDr Bhutani is a professor and Dr Koduru is a research intern in the Department of Gastroenterology, Hepatology, and Nutrition at the University of Texas MD Anderson Cancer Center in Houston, Texas. Dr Joshi is an associate professor in the Department of Gastroenterology at the Ochsner Clinic Foundation in New Orleans, Louisiana. Dr Karstensen is a research fellow, Dr Saftoiu is a visiting professor, and Dr Vilmann is a professor at the University of Copenhagen Herlev Hospital in Herlev, Denmark. Dr Saftoiu is also a professor at the Research Center of Gastroenterology and Hepatology at the University of Medicine and Pharmacy of Craiova in Craiova, Romania. Dr Giovannini is a professor at the Institut Paoli-Calmettes in Marseille, France.
Virendra JoshiDr Bhutani is a professor and Dr Koduru is a research intern in the Department of Gastroenterology, Hepatology, and Nutrition at the University of Texas MD Anderson Cancer Center in Houston, Texas. Dr Joshi is an associate professor in the Department of Gastroenterology at the Ochsner Clinic Foundation in New Orleans, Louisiana. Dr Karstensen is a research fellow, Dr Saftoiu is a visiting professor, and Dr Vilmann is a professor at the University of Copenhagen Herlev Hospital in Herlev, Denmark. Dr Saftoiu is also a professor at the Research Center of Gastroenterology and Hepatology at the University of Medicine and Pharmacy of Craiova in Craiova, Romania. Dr Giovannini is a professor at the Institut Paoli-Calmettes in Marseille, France.
John G KarstensenDr Bhutani is a professor and Dr Koduru is a research intern in the Department of Gastroenterology, Hepatology, and Nutrition at the University of Texas MD Anderson Cancer Center in Houston, Texas. Dr Joshi is an associate professor in the Department of Gastroenterology at the Ochsner Clinic Foundation in New Orleans, Louisiana. Dr Karstensen is a research fellow, Dr Saftoiu is a visiting professor, and Dr Vilmann is a professor at the University of Copenhagen Herlev Hospital in Herlev, Denmark. Dr Saftoiu is also a professor at the Research Center of Gastroenterology and Hepatology at the University of Medicine and Pharmacy of Craiova in Craiova, Romania. Dr Giovannini is a professor at the Institut Paoli-Calmettes in Marseille, France.
Adrian SaftoiuDr Bhutani is a professor and Dr Koduru is a research intern in the Department of Gastroenterology, Hepatology, and Nutrition at the University of Texas MD Anderson Cancer Center in Houston, Texas. Dr Joshi is an associate professor in the Department of Gastroenterology at the Ochsner Clinic Foundation in New Orleans, Louisiana. Dr Karstensen is a research fellow, Dr Saftoiu is a visiting professor, and Dr Vilmann is a professor at the University of Copenhagen Herlev Hospital in Herlev, Denmark. Dr Saftoiu is also a professor at the Research Center of Gastroenterology and Hepatology at the University of Medicine and Pharmacy of Craiova in Craiova, Romania. Dr Giovannini is a professor at the Institut Paoli-Calmettes in Marseille, France.
Peter VilmannDr Bhutani is a professor and Dr Koduru is a research intern in the Department of Gastroenterology, Hepatology, and Nutrition at the University of Texas MD Anderson Cancer Center in Houston, Texas. Dr Joshi is an associate professor in the Department of Gastroenterology at the Ochsner Clinic Foundation in New Orleans, Louisiana. Dr Karstensen is a research fellow, Dr Saftoiu is a visiting professor, and Dr Vilmann is a professor at the University of Copenhagen Herlev Hospital in Herlev, Denmark. Dr Saftoiu is also a professor at the Research Center of Gastroenterology and Hepatology at the University of Medicine and Pharmacy of Craiova in Craiova, Romania. Dr Giovannini is a professor at the Institut Paoli-Calmettes in Marseille, France.
Marc GiovanniniDr Bhutani is a professor and Dr Koduru is a research intern in the Department of Gastroenterology, Hepatology, and Nutrition at the University of Texas MD Anderson Cancer Center in Houston, Texas. Dr Joshi is an associate professor in the Department of Gastroenterology at the Ochsner Clinic Foundation in New Orleans, Louisiana. Dr Karstensen is a research fellow, Dr Saftoiu is a visiting professor, and Dr Vilmann is a professor at the University of Copenhagen Herlev Hospital in Herlev, Denmark. Dr Saftoiu is also a professor at the Research Center of Gastroenterology and Hepatology at the University of Medicine and Pharmacy of Craiova in Craiova, Romania. Dr Giovannini is a professor at the Institut Paoli-Calmettes in Marseille, France.
University of Copenhagen · DKInstitut Paoli-Calmettes · FROchsner Medical Center · USThe University of Texas Health Science Center at Houston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endoscopic ultrasound (EUS) has emerged as an excellent tool for imaging the gastrointestinal tract, as well as surrounding structures. EUS-guided fine-needle aspiration (EUS-FNA) has become the standard of care for the tissue sampling of a variety of masses and lymph nodes within and around the gut, providing further diagnostic and staging information. Confocal laser endomicroscopy (CLE) is a novel endoscopic method that enables imaging at a subcellular level of resolution during endoscopy, allowing up to 1000-fold magnification of tissue and providing an optical biopsy. A new procedure that has been developed in the past few years is needle-based confocal laser endomicroscopy (nCLE), which involves a mini-CLE probe that can be passed through a 1 9-gauge needle during EUS-FNA. This enables the real-time visualization of tissue at a microscopic level, with the potential to further improve the diagnostic accuracy of EUS-FNA. The device has been studied in animals as well as in humans, and the results so far have been promising. Recently, this method has also been used for the visualization of regulatory proteins and receptors in the pancreas, setting a cornerstone for nCLE in molecular imaging. The aim of this article is to review the role of EUS-guided nCLE in modern endoscopy and its implications in molecular imaging.

Indexed as

Endoscopic ultrasoundendosonographyintraductal papillary mucinous neoplasmneedle-based confocal laser endomicroscopypancreatic cystic neoplasmserous cystadenoma

Identifiers

PMID27099595
PMCPMC4836594
OpenAlexW2418310444

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.