ArticleTherapeutics and clinical risk management2016
Guidelines for acute management of hyperammonemia in the Middle East region.
Article in Therapeutics and clinical risk management, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- The impact of ammonia levels and dialysis on outcome in 202 patients with neonatal onset urea cycle disorders.Journal of inherited metabolic disease · 2018Pooled it
- Impact of glycerol phenylbutyrate on biochemistry and outcomes in paediatric patients with urea cycle disorders: a multicentre case series from Saudi Arabia.Orphanet journal of rare diseases · 2026Article
- Continuous renal replacement therapy for severe transient hyperammonemia in a preterm infant weighing 1120 g: A case report.The Journal of international medical research · 2025Article
- Hyperammonemic Encephalopathy and Thyroid Storm Leading to Coma: A Case Report.Case reports in critical care · 2025Article
- Citrin deficiency-The East-side story.Journal of inherited metabolic disease · 2024Review
- Quo vadis ureagenesis disorders? A journey from 90 years ago into the future.Journal of inherited metabolic disease · 2024Review
- Prognostic value of serum ammonia in critical patients with non-hepatic disease: A prospective, observational, multicenter study.Journal of translational internal medicine · 2023Article
- Treatment of Hyperammonemia Syndrome in Lung Transplant Recipients.Journal of clinical medicine · 2023Review
- [Expert consensus on the diagnosis and treatment of neonatal hyperammonemia].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Article
- Anesthesia management in living-donor liver transplantation in a patient with carbamoyl phosphate synthetase deficiency: a case report.JA clinical reports · 2022Article
- Characteristics of continuous venovenous hemodiafiltration in the acute treatment of inherited metabolic disorders.Pediatric nephrology (Berlin, Germany) · 2022Article
- Hepatic Encephalopathy and Melatonin.Antioxidants (Basel, Switzerland) · 2022Review
- Challenges in the diagnosis and management of urea cycle disorders in Romanian children.Medicine and pharmacy reports · 2021Article
- [Application of continuous renal replacement therapy in the treatment of neonates with inherited metabolic diseases].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- Fatal Encephalopathy Caused by a Urea Cycle Disorder.Journal of clinical neurology (Seoul, Korea) · 2021Article
- Assessing the Quality of Clinical Practice Guidelines in the Middle East and North Africa (MENA) Region: A Systematic Review.Journal of multidisciplinary healthcare · 2021Article
- Consensus guidelines for management of hyperammonaemia in paediatric patients receiving continuous kidney replacement therapy.Nature reviews. Nephrology · 2020Review
- Peripheral venous route for administration of ammonul infusion for treatment of acute hyperammonemia. An experience from a tertiary center in Saudi Arabia.Saudi medical journal · 2020Article
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Corrections and comments
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Authors and funding
11 authors at 6 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyperammonemia is a life-threatening event that can occur at any age. If treated, the early symptoms in all age groups could be reversible. If untreated, hyperammonemia could be toxic and cause irreversible brain damage to the developing brain.
objectiveThere are major challenges that worsen the outcome of hyperammonemic individuals in the Middle East. These include: lack of awareness among emergency department physicians about proper management of hyperammonemia, strained communication between physicians at primary, secondary, and tertiary hospitals, and shortage of the medications used in the acute management of hyperammonemia. Therefore, the urge to develop regional guidelines is extremely obvious.
methodWe searched PubMed and Embase databases to include published materials from 2011 to 2014 that were not covered by the European guidelines, which was published in 2012. We followed the process of a Delphi conference and involved one preliminary meeting and two follow-up meetings with email exchanges between the Middle East Hyperammonemia and Urea Cycle Disorders Scientific Group regarding each draft of the manuscript. RESULTS AND DISCUSSION: We have developed consensus guidelines based on the highest available level of evidence. The aim of these guidelines is to homogenize and harmonize the treatment protocols used for patients with acute hyperammonemia, and to provide a resource to not only metabolic physicians, but also physicians who may come in contact with individuals with acute hyperammonemia.
conclusionThese suggested guidelines aim to ease the challenges faced by physicians dealing with acute hyperammonemia in the region. In addition, guidelines have demonstrated useful collaboration between experts in the region, and provides information that will hopefully improve the outcomes of patients with acute hyperammonemia.
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