Evidence map›Paper›PMID 27099230›Full record

ArticleThe Journal of nutrition2016

Paleolithic and Mediterranean Diet Pattern Scores Are Inversely Associated with Biomarkers of Inflammation and Oxidative Balance in Adults.

Kristine A Whalen, Marjorie L McCullough, W Dana Flanders, Terryl J Hartman, Suzanne Judd, Roberd M Bostick

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Article in The Journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kristine A WhalenDepartment of Epidemiology and.ORCID 0000-0003-4418-6233
Marjorie L McCulloughEpidemiology Research Program, American Cancer Society, Atlanta, GA; and.
W Dana FlandersDepartment of Epidemiology and Department of Biostatistics and Bioinformatics, Rollins School of Public Health, and Winship Cancer Institute, Emory University, Atlanta, GA;
Terryl J HartmanDepartment of Epidemiology and Winship Cancer Institute, Emory University, Atlanta, GA;
Suzanne JuddDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL.
Roberd M BostickDepartment of Epidemiology and Winship Cancer Institute, Emory University, Atlanta, GA; rmbosti@emory.edu.

Funding

Oxidative Stress, DNA Repair & Colorectal Adenoma RiskR01CA116795 · NCI · EMORY UNIVERSITY · PI GOODMAN, MICHAEL · 2007 to 2009
$869k
DIET, CELL PROLIFERATION, AND COLON NEOPLASIA STUDYR01CA066539 · NCI · WAKE FOREST UNIVERSITY · PI BOSTICK, ROBERD · 1994 to 1996
–
NCI NIH HHS R01 CA066539NCI NIH HHS R01 CA116795
6 · The paper itself

Abstract

backgroundChronic inflammation and oxidative balance are associated with poor diet quality and risk of cancer and other chronic diseases. A diet-inflammation/oxidative balance association may relate to evolutionary discordance.

objectiveWe investigated associations between 2 diet pattern scores, the Paleolithic and the Mediterranean, and circulating concentrations of 2 related biomarkers, high-sensitivity C-reactive protein (hsCRP), an acute inflammatory protein, and F2-isoprostane, a reliable marker of in vivo lipid peroxidation.

methodsIn a pooled cross-sectional study of 30- to 74-y-old men and women in an elective outpatient colonoscopy population (n = 646), we created diet scores from responses on Willett food-frequency questionnaires and measured plasma hsCRP and F2-isoprostane concentrations by ELISA and gas chromatography-mass spectrometry, respectively. Both diet scores were calculated and categorized into quintiles, and their associations with biomarker concentrations were estimated with the use of general linear models to calculate and compare adjusted geometric means, and via unconditional ordinal logistic regression.

resultsThere were statistically significant trends for decreasing geometric mean plasma hsCRP and F2-isoprostane concentrations with increasing quintiles of the Paleolithic and Mediterranean diet scores. The multivariable-adjusted ORs comparing those in the highest with those in the lowest quintiles of the Paleolithic and Mediterranean diet scores were 0.61 (95% CI: 0.36, 1.05; P-trend = 0.06) and 0.71 (95% CI: 0.42, 1.20; P-trend = 0.01), respectively, for a higher hsCRP concentration, and 0.51 (95% CI: 0.27, 0.95; P-trend 0.01) and 0.39 (95% CI: 0.21, 0.73; P-trend = 0.01), respectively, for a higher F2-isoprostane concentration.

conclusionThese findings suggest that diets that are more Paleolithic- or Mediterranean-like may be associated with lower levels of systemic inflammation and oxidative stress in humans.

Indexed as

Diet, MediterraneanDiet, PaleolithicAdultAgedBiomarkersC-Reactive ProteinCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayF2-IsoprostanesFemaleGas Chromatography-Mass SpectrometryHumansInflammationMaleMiddle AgedOxidative StressBiomarkersC-Reactive ProteinF2-IsoprostanesC-reactive proteincross-sectional studydiet patternsF2-isoprostanesinflammationMediterranean dietoxidative balancePaleolithic diet

Identifiers

PMID27099230
PMCPMC4877627

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.