ArticleMedical & biological engineering & computing2016
A comparative study of strontium-substituted hydroxyapatite coating on implant's osseointegration for osteopenic rats.
Article in Medical & biological engineering & computing, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of titanium implants with strontium incorporation on bone apposition in animal models: A systematic review and meta-analysis.Scientific reports · 2017Pooled it
- Strategic incorporation of metal ions in bone regenerative scaffolds: multifunctional platforms for advancing osteogenesis.Regenerative biomaterials · 2025Review
- Combination treatment with whole body vibration and simvastatin improves the early osseointegration in aged rats.Bone reports · 2024Article
- Review
- Applications of Bioactive Strontium Compounds in Dentistry.Journal of functional biomaterials · 2024Review
- Selenium-modified calcium phosphate cement can accelerate bone regeneration of osteoporotic bone defect.Journal of bone and mineral metabolism · 2021Article
- Biomimetic Composite Coatings for Activation of Titanium Implant Surfaces: Methodological Approach and In Vivo Enhanced Osseointegration.Micromachines · 2021Article
- Advances in Osteoporotic Bone Tissue Engineering.Journal of clinical medicine · 2021Review
- Co-modification of calcium phosphate cement to achieve rapid bone regeneration in osteoporotic femoral condyle defect with lithium and aspirin.American journal of translational research · 2021Article
- Melatonin improves the osseointegration of hydroxyapatite-coated titanium implants in senile female rats.Zeitschrift fur Gerontologie und Geriatrie · 2020Article
- In vitro osteogenesis of rat bone marrow mesenchymal cells on PEEK disks with heat-fixed apatite by COBMC musculoskeletal disorders · 2020Article
- Resveratrol reverses the negative effect of alcohol on hydroxyapatite-coated implant osseointegration in senile female rats.Zeitschrift fur Gerontologie und Geriatrie · 2020Article
- Substituted hydroxyapatite coatings of bone implants.Journal of materials chemistry. B · 2020Review
- Combined antisclerostin antibody and parathyroid hormone (1-34) synergistically enhance the healing of bone defects in ovariectomized rats.Zeitschrift fur Gerontologie und Geriatrie · 2020Article
- Building Osteogenic Microenvironments With Strontium-Substituted Calcium Phosphate Ceramics.Frontiers in bioengineering and biotechnology · 2020Review
- Tantalum-incorporated hydroxyapatite coating on titanium implants: its mechanical and in vitro osteogenic properties.Journal of materials science. Materials in medicine · 2019Article
- Article
- Single-dose local administration of parathyroid hormone (1-34, PTH) with β-tricalcium phosphate/collagen (β-TCP/COL) enhances bone defect healing in ovariectomized rats.Journal of bone and mineral metabolism · 2019Article
- The effects of sclerostin antibody plus parathyroid hormone (1-34) on bone formation in ovariectomized rats.Zeitschrift fur Gerontologie und Geriatrie · 2018Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surface modification techniques have been applied to generate titanium implant surfaces that promote osseointegration for the implants in cementless arthroplasty. However, its effect is not sufficient for osteoporotic bone. Strontium (Sr) promotes osteoblast proliferation and inhibits osteoclast proliferation and positively affects bone regeneration. The aim of this study was to confirm the effects of strontium-substituted hydroxyapatite (Sr-HA) coating via electrochemical deposition on implant's osseointegration in the osteoporotic condition. Female Sprague Dawley rats were used for this study. Twelve weeks after bilateral ovariectomy, all animals were randomly divided into four groups: group HA; group 5 % Sr-HA; group 10 % Sr-HA; and group 20 % Sr-HA. Afterward, all rats from groups HA, 5 % Sr-HA, 10 % Sr-HA, and 20 % Sr-HA received implants with hydroxyapatite coating containing 0, 5, 10, and 20 % Sr. Implants were inserted bilaterally in all animals until death at 12 weeks. The bilateral femurs of rats were harvested for evaluation. All treatment groups increased new bone formation around the surface of titanium rods and push-out force; group 20 % Sr-HA showed the strongest effects on new bone formation and biomechanical strength. Additionally, these are significant differences in bone formation and push-out force was observed between groups 5 % Sr-HA and 10 % Sr-HA. This finding suggests that Sr-HA coating can improve implant osseointegration, and the 20 % Sr coating exhibited the best properties for implant osseointegration among the tested coatings in osteoporosis rats.
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