ReviewAerospace medicine and human performance2016
Central Nervous System Oxygen Toxicity and Hyperbaric Oxygen Seizures.
Review in Aerospace medicine and human performance, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Electroencephalographic (EEG) changes accompanying normal breathing of concentrated oxygen (hyperoxic ventilation) by healthy adults: a systematic review.Diving and hyperbaric medicine · 2025Pooled it
- Oxygen Targets After Cardiac Arrest: A Meta-analysis of Randomized Controlled Trials.American journal of therapeuticsPooled it
- Effect of a prior hypercapnia experience on recognition of hypercapnia in divers: a randomised controlled study.Diving and hyperbaric medicine · 2026Trial
- Pre-Activation of Mitophagy Protects Against Hyperbaric Oxygen-Induced Central Nervous System Oxygen Toxicity.International journal of molecular sciences · 2026Article
- Partial pressure of oxygen, hyperoxemia and hyperoxia in the intensive care or anesthesia setting.Medical gas research · 2026Review
- Effect of a Localized Oxygen-Releasing Hydrogel Sheet on Early-Stage Infarct Evolution in a Rat Photothrombotic Stroke Model: A Preliminary Study.Gels (Basel, Switzerland) · 2026Article
- Acute Lung Injury Induced by Hyperbaric Oxygen or Other External Factors, with a Focus on Exosomes.International journal of molecular sciences · 2026Review
- HBOT as a Potential Adjunctive Therapy for Wound Healing in Dental Surgery-A Narrative Review.Journal of clinical medicine · 2026Review
- Assessing dive fitness in individuals with autism spectrum disorder.Diving and hyperbaric medicine · 2025Review
- Wireless charging LED mediated type I photodynamic therapy of breast cancer using NIR AIE photosensitizer.iScience · 2025Article
- Safety of hyperbaric oxygen therapy in non-emergent patients with a history of seizures: A retrospective cohort study.PloS one · 2025Article
- Incidence and risk factors of hyperoxemia among potentially critically ill patients treated in hospital wards: a retrospective study.Turkish journal of medical sciences · 2025Article
- Caffeine, MitoQ, and GABA Prophylaxis of Mitochondrial Dysfunction Induced in Human Pulmonary Cells by Normobaric-Hyperoxia and Hyperbaric-Hyperoxia.Oxidative medicine and cellular longevity · 2025Article
- Hyperbaric oxygen therapy attenuates brain radiation-induced cognitive deficits in rats.International journal of medical sciences · 2025Article
- Meclizine seasickness medication and its effect on central nervous system oxygen toxicity in a murine model.Diving and hyperbaric medicine · 2024Article
- Methylphenidate and the risk of acute central nervous system oxygen toxicity: a rodent model and observational data in human divers.Diving and hyperbaric medicine · 2024Observational
- PEG300 Protects Mitochondrial Function By Upregulating PGC-1α to Delay Central Nervous System Oxygen Toxicity in Mice.Neurotoxicity research · 2024Article
- Physiological monitoring to prevent diving disorders.Frontiers in physiology · 2024Review
- Review
- Diving with psychotropic medication: review of the literature and clinical considerations.Diving and hyperbaric medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
introductionThe use of hyperbaric oxygen (O2) as a therapeutic agent carries with it the risk of central nervous system (CNS) O2 toxicity.
methodsTo further the understanding of this risk and the nature of its molecular mechanism, a review was conducted on the literature from various fields.
resultsNumerous physiological changes are produced by increased partial pressures of oxygen (Po2), which may ultimately result in CNS O2 toxicity. The human body has several equilibrated safeguards that minimize effects of reactive species on neural networks, believed to play a primary role in CNS O2 toxicity. Increased partial pressure of oxygen (Po2) appears to saturate protective enzymes and unfavorably shift protective reactions in the direction of neural network overstimulation. Certain regions of the CNS appear more susceptible than others to these effects. Failure to decrease the elevated Po2 can result in a tonic-clonic seizure and death. Randomized, controlled studies in human populations would require a multicenter trial over a long period of time with numerous endpoints used to identify O2 toxicity.
conclusionsThe mounting scientific evidence and apparent increase in the number of hyperbaric O2 treatments demonstrate a need for further study in the near future.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.