ArticleGenetics2016
Limits to Adaptation in Partially Selfing Species.
Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Comparative Analysis of Diversification Rates in Clonal and Non-Clonal Flowering Plants.Ecology letters · 2026Article
- Investigating the consequences of the mating system for drug resistance evolution inProceedings. Biological sciences · 2025Article
- Hill-Robertson interference may bias the inference of fitness effects of new mutations in highly selfing species.Evolution; international journal of organic evolution · 2025Article
- Genomic implications of the repeated shift to self-fertilization across a species' geographic distribution.The Journal of heredity · 2025Article
- Hill-Robertson interference may bias the inference of fitness effects of new mutations in highly selfing species.bioRxiv : the preprint server for biology · 2024Article
- Polygenic selection to a changing optimum under self-fertilisation.PLoS genetics · 2024Article
- Scattered differentiation of unlinked loci across the genome underlines ecological divergence of the selfing grassProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Influence of the mutation load on the genomic composition of hybrids between outcrossing and self-fertilizing species.Ecology and evolution · 2023Article
- Genomic diversity landscapes in outcrossing and selfing Caenorhabditis nematodes.PLoS genetics · 2023Article
- Drivers of strong isolation and small effective population size at a leading range edge of a widespread plant.Heredity · 2023Article
- Are genetic variation and demographic performance linked?Evolutionary applications · 2022Article
- Article
- Evolution of flowering time in a selfing annual plant: Roles of adaptation and genetic drift.Ecology and evolution · 2022Article
- How and When Does Outcrossing Occur in the Predominantly Selfing SpeciesFrontiers in plant science · 2021Article
- Evolution of self-incompatibility in the Brassicaceae: Lessons from a textbook example of natural selection.Evolutionary applications · 2020Article
- Inferring the Demographic History of Inbred Species from Genome-Wide SNP Frequency Data.Molecular biology and evolution · 2020Article
- Selective Sweeps Under Dominance and Inbreeding.G3 (Bethesda, Md.) · 2020Article
- Effect of partial selfing and polygenic selection on establishment in a new habitat.Evolution; international journal of organic evolution · 2019Article
- Sexual selection and inbreeding: Two efficient ways to limit the accumulation of deleterious mutations.Evolution letters · 2019Article
- The interaction between sex-specific selection and local adaptation in species without separate sexes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
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Authors and funding
2 authors.
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Abstract
In outcrossing populations, "Haldane's sieve" states that recessive beneficial alleles are less likely to fix than dominant ones, because they are less exposed to selection when rare. In contrast, selfing organisms are not subject to Haldane's sieve and are more likely to fix recessive types than outcrossers, as selfing rapidly creates homozygotes, increasing overall selection acting on mutations. However, longer homozygous tracts in selfers also reduce the ability of recombination to create new genotypes. It is unclear how these two effects influence overall adaptation rates in partially selfing organisms. Here, we calculate the fixation probability of beneficial alleles if there is an existing selective sweep in the population. We consider both the potential loss of the second beneficial mutation if it has a weaker advantage than the first one, and the possible replacement of the initial allele if the second mutant is fitter. Overall, loss of weaker adaptive alleles during a first selective sweep has a larger impact on preventing fixation of both mutations in highly selfing organisms. Furthermore, the presence of linked mutations has two opposing effects on Haldane's sieve. First, recessive mutants are disproportionally likely to be lost in outcrossers, so it is likelier that dominant mutations will fix. Second, with elevated rates of adaptive mutation, selective interference annuls the advantage in selfing organisms of not suffering from Haldane's sieve; outcrossing organisms are more able to fix weak beneficial mutations of any dominance value. Overall, weakened recombination effects can greatly limit adaptation in selfing organisms.
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