ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016
The Contribution of the Corpus Callosum to Language Lateralization.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03972202 (The Role of Cerebellum in Speech), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Cerebellum in Speech
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- A systematic literature review of sex differences in childhood language and brain development.Neuropsychologia · 2018Pooled it
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- Intrahemispheric White Matter Asymmetries and Interhemispheric Connections Underlying the Lateralization of Language Production and Spatial Attention in Left-Handers.Neurobiology of language (Cambridge, Mass.) · 2025Article
- A versatile pipeline to identify convergently lost ancestral conserved fragments associated with convergent evolution of vocal learning.Briefings in bioinformatics · 2024Article
- Musicianship and Prominence of Interhemispheric Connectivity Determine Two Different Pathways to Atypical Language Dominance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Predicting Response to Neuropsychological Intervention in Developmental Dyslexia: A Retrospective Study.Brain sciences · 2024Article
- Spatiotemporal Patterns of White Matter Maturation after Pre-Adolescence: A Diffusion Kurtosis Imaging Study.Brain sciences · 2024Article
- Demographic and clinical characteristics, seizure disorders, and antiepileptic drug usage in different types of corpus callosum disorders: a comparative study in children.Italian journal of pediatrics · 2024Article
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- White matter plasticity during second language learning within and across hemispheres.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Reduced lateralization of the language network in the blind and its relationship with white matter tract neuroanatomy.Frontiers in human neuroscience · 2024Article
- The corpus callosum and creativity revisited.Frontiers in human neuroscience · 2024Article
- Improved prediction of glioma-related aphasia by diffusion MRI metrics, machine learning, and automated fiber bundle segmentation.Human brain mapping · 2023Article
- Plasticity of callosal neurons in the contralesional cortex following traumatic brain injury.Neural regeneration research · 2023Article
- Time course of right-hemisphere recruitment during word production following left-hemisphere damage: A single case of young stroke.The European journal of neuroscience · 2022Article
- Language lateralization in very preterm children: associating dichotic listening to interhemispheric connectivity and language performance.Pediatric research · 2022Article
- Temporal specificity of abnormal neural oscillations during phonatory events in laryngeal dystonia.Brain communications · 2022Article
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Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
The development of hemispheric lateralization for language is poorly understood. In one hypothesis, early asymmetric gene expression assigns language to the left hemisphere. In an alternate view, language is represented a priori in both hemispheres and lateralization emerges via cross-hemispheric communication through the corpus callosum. To address this second hypothesis, we capitalized on the high temporal and spatial resolution of magnetoencephalographic imaging to measure cortical activity during language processing, speech preparation, and speech execution in 25 participants with agenesis of the corpus callosum (AgCC) and 21 matched neurotypical individuals. In contrast to strongly lateralized left hemisphere activations for language in neurotypical controls, participants with complete or partial AgCC exhibited bilateral hemispheric activations in both auditory or visually driven language tasks, with complete AgCC participants showing significantly more right hemisphere activations than controls or than individuals with partial AgCC. In AgCC individuals, language laterality positively correlated with verbal IQ. These findings suggest that the corpus callosum helps to drive language lateralization. SIGNIFICANCE STATEMENT: The role that corpus callosum development has on the hemispheric specialization of language is poorly understood. Here, we used magnetoencephalographic imaging during linguistic tests (verb generation, picture naming) to test for hemispheric dominance in patients with agenesis of the corpus callosum (AgCC) and found reduced laterality (i.e., greater likelihood of bilaterality or right hemisphere dominance) in this cohort compared with controls, especially in patients with complete agenesis. Laterality was positively correlated with behavioral measures of verbal intelligence. These findings provide support for the hypothesis that the callosum aids in functional specialization throughout neural development and that the loss of this mechanism correlates with impairments in verbal performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.